ArticleDigestive diseases and sciences2007
Prognostic significance of RCAS1 expression in relation to the infiltration of dendritic cells and lymphocytes in patients with esophageal carcinoma.
Article in Digestive diseases and sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The prognostic value of separate lymphatic invasion and vascular invasion in oesophageal squamous cell carcinoma: a meta-analysis and systematic review.BMC cancer · 2022Pooled it
- Innate Immune Cells in the Esophageal Tumor Microenvironment.Frontiers in immunology · 2021Review
- Stimulation of DC-CIK with PADI4 Protein Can Significantly Elevate the Therapeutic Efficiency in Esophageal Cancer.Journal of immunology research · 2019Article
- Expression of RCAS1 correlates with urothelial bladder cancer malignancy.International journal of molecular sciences · 2015Article
- Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma.Journal of translational medicine · 2014Article
- Increased RCAS1 expression is associated with advanced histopathological stage and poor prognosis in patients with gastric adenocarcinoma.Disease markers · 2013Article
- Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- RCAS1 expression in mobile tongue squamous cell carcinoma: an immunohistochemical study.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- The immunoregulatory mechanisms of carcinoma for its survival and development.Journal of experimental & clinical cancer research : CR · 2011Review
- The Involvement of RCAS1 in Creating a Suppressive Tumor Microenvironment in Patients with Salivary Gland Adenocarcinoma.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2010Article
- Clinical significance of tumor-associated antigen RCAS1 expression in human pancreatic ductal adenocarcinoma.Digestive diseases and sciences · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) expression was determined in 107 esophageal carcinoma patients by immunohistochemical procedures and compared with tumor infiltrating lymphocyte (TIL) and dendritic cell (DC) infiltration to evaluate the effect of RCAS1 on immune responses in esophageal carcinoma. RCAS1 immunoreactivity was detected in 59 of 107 patients (55.1%). RCAS1 expression was significantly correlated with the depth of invasion, lymph node metastasis, and histologic stage. RCAS1 expression tended to be correlated with a lower TIL density in tumors with marked DC infiltration. The survival time for patients with RCAS1-negative tumors was significantly longer than that for patients with RCAS1-positive tumors. Especially, the prognosis was predicted by RCAS1 in cases with marked DC infiltration. Multivariate analysis revealed that RCAS1 expression was an independent prognostic factor. RCAS1 expression may play an important role in evading the immunological defense mechanisms in esophageal carcinoma.
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