ArticleDigestive diseases and sciences2007
Electroacupuncture and moxibustion promote neutrophil apoptosis and improve ulcerative colitis in rats.
Article in Digestive diseases and sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Moxibustion for ulcerative colitis: a systematic review and meta-analysis.BMC gastroenterology · 2010Pooled it
- Randomized controlled trial: moxibustion and acupuncture for the treatment of Crohn's disease.World journal of gastroenterology · 2014Trial
- Electroacupuncture alleviates intestinal inflammation in rats with ulcerative colitis by regulating colonic cell autophagy and gut microbiota.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Mechanism study of acupuncture and acupuncture combined with medication in the treatment of ulcerative colitis.Physiological research · 2025Review
- Management of Fatigue in Inflammatory Bowel Disease: A Narrative Review.International journal of general medicine · 2025Review
- Electroacupuncture alleviates ulcerative colitis by targeting CXCL1: evidence from the transcriptome and validation.Frontiers in immunology · 2023Article
- Genome-Wide Regulation of Acupuncture and Moxibustion on Ulcerative Colitis Rats.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Herb-partitioned moxibustion alleviates colon injuries in ulcerative colitis rats.World journal of gastroenterology · 2018Article
- Moxibustion treatment modulates the gut microbiota and immune function in a dextran sulphate sodium-induced colitis rat model.World journal of gastroenterology · 2018Article
- Effects of Herb-Partitioned Moxibustion on the miRNA Expression Profiles in Colon from Rats with DSS-Induced Ulcerative Colitis.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Electroacupuncture Attenuates Visceral Hypersensitivity by Inhibiting JAK2/STAT3 Signaling Pathway in the Descending Pain Modulation System.Frontiers in neuroscience · 2017Article
- Moxibustion regulates inflammatory mediators and colonic mucosal barrier in ulcerative colitis rats.World journal of gastroenterology · 2016Article
- Herb-Partitioned Moxibustion Regulates the TLR2/NF-κB Signaling Pathway in a Rat Model of Ulcerative Colitis.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Electroacupuncture improves trinitrobenzene sulfonic Acid-induced colitis, evaluated by transcriptomic study.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Transcutaneous electrical nerve stimulation regulates organ blood flow and apoptosis during controlled hypotension in dogs.PloS one · 2014Article
- Electroacupuncture at He-Mu points reduces P2X4 receptor expression in visceral hypersensitivity.Neural regeneration research · 2013Article
- Electroacupuncture diminishes P2X2 and P2X3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity.Neural regeneration research · 2013Article
- The mechanism of effective electroacupuncture on T cell response in rats with experimental autoimmune encephalomyelitis.PloS one · 2013Article
- Moxibustion inhibits interleukin-12 and tumor necrosis factor alpha and modulates intestinal flora in rat with ulcerative colitis.World journal of gastroenterology · 2012Article
- Electroacupuncture inhibits apoptosis in annulus fibrosis cells through suppression of the mitochondria-dependent pathway in a rat model of cervical intervertebral disc degradation.Genetics and molecular biology · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate the effect of electroacupuncture (EA) and moxibustion on promoting neutrophil apoptosis. A rat model of ulcerative colitis was established by immunological methods using human colonic mucosa as antigen. All rats were randomly assigned to the model control (MC) group, EA group, or herbs-partition moxibustion (HPM) group. Normal rats were used as the normal control (NC) group. Peripheral blood mononuclear cells (PBMCs) from all rats and circular neutrophils from NC rats were isolated and cultured. Circular neutrophils were incubated with cultured supernatants of PBMCs from the MC, NC, EA, and HPM groups, respectively. Neutrophil apoptosis and concentration of IL-1beta, IL-6, and TNF-alpha from induced cultured supernatants were detected by cell cytometry and ELISA, respectively. Compared with MC, HPM, and EA rats, mucosal inflammatory lesions abated remarkably. No hyperemia or edema was seen in the lamina propria, inflammatory cell infiltration decreased, neutrophil infiltration disappeared, and epithelial and crypt cells proliferated and repaired the ulceration of the mucosa. Neutrophil apoptosis was promoted. Concentrations of IL-1beta, IL-6, and TNF-alpha were decreased, respectively. We conclude that EA and HPM therapy can improve ulcerative colitis rats histologically, which may be due to promoting neutrophil apoptosis and down-regulating monocyte cytokines. EA and moxibustion are effective for treating ulcerative colitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.