Evidence map›Paper›PMID 17211497›Full record

Trial reportInternational journal of medical sciences2006

Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes.

Naomi Brooks, Jennifer E Layne, Patricia L Gordon, Ronenn Roubenoff, Miriam E Nelson, Carmen Castaneda-Sceppa

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of medical sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02674659 (The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9), which is not on this map. Cited by 127 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 12 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02674659 nacompletednot on this mapstarted 2016, after this paper: background citation

The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 (PCSK-9) Level in Patients After Coronary Bypass Surgery

TypeinterventionalSponsorNational Cardiovascular Center Harapan Kita Hospital IndonesiaRan2016 to 2016Enrolled87ConditionsCoronary Artery DiseaseArmsresistance training, aerobic training
3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 12 syntheses or guidelines pooled it, 346 citations in OpenAlex.

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  17. Psychosocial Correlates of Meeting National Guidelines for Muscle-Strengthening Activities in Latinas.Health education & behavior : the official publication of the Society for Public Health Education · 2022
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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Naomi BrooksJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Jennifer E Layne
Patricia L Gordon
Ronenn Roubenoff
Miriam E Nelson
Carmen Castaneda-Sceppa
Tufts University · USJean Mayer Human Nutrition Research Center on Aging · USUniversity of California, San Francisco · US

Funding

ZIDOVUDINE &LAMIVUDINE ALONE OR IN COMBINATION ON BODY COMPOSITIONM01RR000054 · NCRR · TUFTS MEDICAL CENTER · PI WANKE, CHRISTINE A · 1985 to 2005
$12.2M
NCRR NIH HHS M01 RR000054
6 · The paper itself

Abstract

Hispanics are at increased risk of morbidity and mortality due to their high prevalence of diabetes and poor glycemic control. Strength training is the most effective lifestyle intervention to increase muscle mass but limited data is available in older adults with diabetes. We determined the influence of strength training on muscle quality (strength per unit of muscle mass), skeletal muscle fiber hypertrophy, and metabolic control including insulin resistance (Homeostasis Model Assessment -HOMA-IR), C-Reactive Protein (CRP), adiponectin and Free Fatty Acid (FFA) levels in Hispanic older adults. Sixty-two community-dwelling Hispanics (>55 y) with type 2 diabetes were randomized to 16 weeks of strength training plus standard care (ST group) or standard care alone (CON group). Skeletal muscle biopsies and biochemical measures were taken at baseline and 16 weeks. The ST group show improved muscle quality (mean+/-SE: 28+/-3) vs CON (-4+/-2, p<0.001) and increased type I (860+/-252 microm(2)) and type II fiber cross-sectional area (720+/-285 microm(2)) compared to CON (type I: -164+/-290 microm(2), p=0.04; and type II: -130+/-336 microm(2), p=0.04). This was accompanied by reduced insulin resistance [ST: median (interquartile range) -0.7(3.6) vs CON: 0.8(3.8), p=0.05]; FFA (ST: -84+/-30 micromol/L vs CON: 149+/-48 micromol/L, p=0.02); and CRP [ST: -1.3(2.9) mg/L vs CON: 0.4(2.3) mg/L, p=0.05]. Serum adiponectin increased with ST [1.0(1.8) microg/mL] compared to CON [-1.2(2.2) microg/mL, p<0.001]. Strength training improved muscle quality and whole-body insulin sensitivity. Decreased inflammation and increased adiponectin levels were related with improved metabolic control. Further studies are needed to understand the mechanisms associated with these findings. However, these data show that strength training is an exercise modality to consider as an adjunct of standard of care in high risk populations with type 2 diabetes.

Indexed as

ExerciseInsulin ResistanceMuscle StrengthAgedC-Reactive ProteinDiabetes Mellitus, Type 2Fatty Acids, NonesterifiedFemaleHispanic or LatinoHumansHypertrophyMaleMuscle Fibers, SkeletalMuscle, SkeletalPhysical EnduranceC-Reactive ProteinFatty Acids, Nonesterified

Identifiers

PMID17211497
PMCPMC1752232
OpenAlexW2137718525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.