ReviewBritish journal of pharmacology2007
Cellular mechanisms underlying the pharmacological induction of phosphenes.
Review in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 86 citations in OpenAlex.
- Effect of ivabradine, a novel antianginal agent, on driving performance: A randomized, double-blind, placebo-controlled trial in healthy volunteers.Clinical drug investigation · 2009Trial
- Ivabradine as a Cardio-Protective Agent Against Anthracycline-Induced Cardiotoxicity: A Narrative Review.Cardiovascular drugs and therapy · 2026Review
- Stroboscopically induced visual hallucinations: historical, phenomenological, and neurobiological perspectives.Neuroscience of consciousness · 2025Review
- Localization of hyperpolarization-activated cyclic nucleotide-gated channels in the vertebrate retinas across species and their physiological roles.Frontiers in neuroanatomy · 2024Review
- Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management.Chemical reviews · 2023Review
- Impaired Color Recognition inFrontiers in neurology · 2022Article
- Ivabradine in Cardiovascular Disease Management Revisited: a Review.Cardiovascular drugs and therapy · 2021Review
- Hemodynamic effects of ivabradine use in combination with intravenous inotropic therapy in advanced heart failure.Heart failure reviews · 2021Review
- Mechanisms of phosphenes in irradiated patients.Oncotarget · 2017Review
- HCN channels--modulators of cardiac and neuronal excitability.International journal of molecular sciences · 2015Review
- fMRI of retina-originated phosphenes experienced by patients with Leber congenital amaurosis.PloS one · 2014Article
- New onset migraine with aura after treatment initiation with ivabradine.The journal of headache and pain · 2013Article
- Comparison of the efficacy and tolerability of ivabradine and ranolazine in patients of chronic stable angina pectoris.Journal of pharmacology & pharmacotherapeutics · 2013Article
- Near death experiences: a multidisciplinary hypothesis.Frontiers in human neuroscience · 2013Article
- Ivabradine: an intelligent drug for the treatment of ischemic heart disease.Molecules (Basel, Switzerland) · 2012Review
- Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue.British journal of pharmacology · 2012Article
- Ih current is necessary to maintain normal dopamine fluctuations and sleep consolidation in Drosophila.PloS one · 2012Article
- Exploring HCN channels as novel drug targets.Nature reviews. Drug discovery · 2011Review
- Ivabradine: a new rate-limiting therapy for coronary artery disease and heart failure.Therapeutic advances in drug safety · 2011Review
- High-pass filtering of input signals by the Ih current in a non-spiking neuron, the retinal rod bipolar cell.PloS one · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visual sensations evoked by stimuli other than luminance changes are called phosphenes. Phosphenes may be an early symptom in a variety of diseases of the retina or of the visual pathways, but healthy individuals may perceive them as well. Phosphene-like phenomena are perhaps the most common side effect reported in clinical pharmacology. Ivabradine, a novel anti-anginal drug that reduces heart-rate by inhibiting the hyperpolarization activated current expressed in cardiac sinoatrial node cells (I(f)) induces phosphenes in some patients. One hypothesis is that ivabradine interacts with the visual system by inhibiting hyperpolarization-activated current in retinal cells (Ih). An Ih current with properties similar to cardiac I(f) has been reported in retinal neurones. Under normal circumstances most of the random fluctuations generated within the retinal circuits do not reach the level of conscious perception because they are filtered out. Presumably, filtering occurs mostly within the retina and one serious candidate for this action is the ability of Ih to act as a negative-feedback mechanism. Ih activation in the membrane of visual cells causes dampening of responses to slow noisy inputs thus tuning the visual system to perceptually more relevant signals of higher frequency. Ih inhibition, by altering at the retinal synapses the filtering of signals generated by thermal breakdown of rhodopsin or other fluctuations, is expected to increase the probability of phosphene occurrence. It is the purpose of the present paper to outline and discuss the features of the visual system and the pharmacological conditions relevant to phosphene perception.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.