ArticleProceedings of the National Academy of Sciences of the United States of America2007
Modern origin of numerous alternatively spliced human introns from tandem arrays.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Insights Into the Molecular Evolution of AT-Hook Motif Nuclear Localization Genes inFrontiers in plant science · 2021Article
- GC-AG Introns Features in Long Non-coding and Protein-Coding Genes Suggest Their Role in Gene Expression Regulation.Frontiers in genetics · 2020Article
- Identification ofOncotarget · 2017Article
- Alternative splicing of a group II intron in a surface layer protein gene in Clostridium tetani.Nucleic acids research · 2014Article
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Article
- Intron creation and DNA repair.Cellular and molecular life sciences : CMLS · 2011Review
- Article
- The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution.BMC evolutionary biology · 2010Article
- Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication.BMC evolutionary biology · 2010Article
- Ubiquitous internal gene duplication and intron creation in eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes.BMC evolutionary biology · 2009Article
- Tandem repeats modify the structure of human genes hosted in segmental duplications.Genome biology · 2009Article
- Where do introns come from?PLoS biology · 2008Article
- Alternative splicing and the steady-state ratios of mRNA isoforms generated by it are under strong stabilizing selection in Caenorhabditis elegans.Molecular biology and evolution · 2008Article
- Ancestry and evolution of a secretory pathway serpin.BMC evolutionary biology · 2008Article
- Alternative splicing: a missing piece in the puzzle of intron gain.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Dual-specificity splice sites function alternatively as 5' and 3' splice sites.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The pathology of pre-mRNA splicing: a meeting in the Italian Alps. Workshop on pre-mRNA processing and disease.EMBO reports · 2007Article
- Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome.Genome biology · 2007Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Despite the widespread occurrence of spliceosomal introns in the genomes of higher eukaryotes, their origin remains controversial. One model proposes that the duplication of small genomic portions could have provided the boundaries for new introns. If this mechanism has occurred recently, the 5' and 3' boundaries of each resulting intron should display distinctive sequence similarity. Here, we report that the human genome contains an excess of introns with perfect matching sequences at boundaries. One-third of these introns interrupt the protein-coding sequences of known genes. Introns with the best-matching boundaries are invariably found in tandem arrays of direct repeats. Sequence analysis of the arrays indicates that many intron-breeding repeats have disseminated in several genes at different times during human evolution. A comparison with orthologous regions in mouse and chimpanzee suggests a young age for the human introns with the most-similar boundaries. Finally, we show that these human introns are alternatively spliced with exceptionally high frequency. Our study indicates that genomic duplication has been an important mode of intron gain in mammals. The alternative splicing of transcripts containing these intron-breeding repeats may provide the plasticity required for the rapid evolution of new human proteins.
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