ArticleProceedings of the National Academy of Sciences of the United States of America2007
Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- E protein binding at theFrontiers in immunology · 2023Article
- Methods for Study of Mouse T Cell Receptor α and β Gene Rearrangements.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire.The Journal of experimental medicine · 2022Article
- Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.Cell reports · 2017Article
- repgenHMM: a dynamic programming tool to infer the rules of immune receptor generation from sequence data.Bioinformatics (Oxford, England) · 2016Article
- Isolation and Ex Vivo Culture of Vδ1+CD4+γδ T Cells, an Extrathymic αβT-cell Progenitor.Journal of visualized experiments : JoVE · 2015Article
- A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires.Nature immunology · 2015Article
- Article
- T-cell receptor α enhancer is inactivated in αβ T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes.Transcription · 2015Review
- Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT Cells.Frontiers in immunology · 2014Article
- Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci.Journal of immunology (Baltimore, Md. : 1950) · 2013Review
- The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.Immunity · 2012Article
- A model for the evolution of the mammalian t-cell receptor α/δ and μ loci based on evidence from the duckbill Platypus.Molecular biology and evolution · 2012Article
- Highly diverse TCRα chain repertoire of pre-immune CD8⁺ T cells reveals new insights in gene recombination.The EMBO journal · 2012Article
- Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization.Immunologic research · 2011Article
- Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.The Journal of experimental medicine · 2010Article
- Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination.The Journal of experimental medicine · 2010Article
- Article
- Numerical modelling of the V-J combinations of the T cell receptor TRA/TRD locus.PLoS computational biology · 2010Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
During the recombination of variable (V) and joining (J) gene segments at the T cell receptor alpha locus, a ValphaJalpha joint resulting from primary rearrangement can be replaced by subsequent rounds of secondary rearrangement that use progressively more 5' Valpha segments and progressively more 3' Jalpha segments. To understand the mechanisms that target secondary T cell receptor alpha recombination, we studied the behavior of a T cell receptor alpha allele (HYalpha) engineered to mimic a natural primary rearrangement of TRAV17 to Jalpha57. The introduced ValphaJalpha segment was shown to provide chromatin accessibility to Jalpha segments situated within several kilobases downstream and to suppress germ-line Jalpha promoter activity and accessibility at greater distances. As a consequence, the ValphaJalpha segment directed secondary recombination events to a subset of Jalpha segments immediately downstream from the primary rearrangement. The data provide the mechanistic basis for a model of primary and secondary T cell receptor alpha recombination in which recombination events progress in multiple small steps down the Jalpha array.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.