ArticleArchives of ophthalmology (Chicago, Ill. : 1960)2007
Identification of novel genetic loci for intraocular pressure: a genomewide scan of the Beaver Dam Eye Study.
Article in Archives of ophthalmology (Chicago, Ill. : 1960), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Common genetic determinants of intraocular pressure and primary open-angle glaucoma.PLoS genetics · 2012Pooled it
- The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables.Journal of glaucoma · 2013Trial
- Caffeine and Vision: Effects on the Eye.Turkish journal of ophthalmology · 2024Review
- Article
- Comparison of MicroRNA Expression in Aqueous Humor of Normal and Primary Open-Angle Glaucoma Patients Using PCR Arrays: A Pilot Study.Investigative ophthalmology & visual science · 2017Article
- Genome-wide linkage and association analysis of primary open-angle glaucoma endophenotypes in the Norfolk Island isolate.Molecular vision · 2017Article
- Exome array analysis identifies CAV1/CAV2 as a susceptibility locus for intraocular pressure.Investigative ophthalmology & visual science · 2014Article
- Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan.Cancer epidemiology · 2014Article
- Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment.Eye (London, England) · 2012Review
- 1α,25-Dihydroxyvitamin D(3) and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), suppress intraocular pressure in non-human primates.Archives of biochemistry and biophysics · 2012Article
- Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma.PLoS genetics · 2011Article
- Complex genetic mechanisms in glaucoma: an overview.Indian journal of ophthalmology · 2011Review
- Glaucoma: genes, phenotypes, and new directions for therapy.The Journal of clinical investigation · 2010Review
- An eye for discovery.The Journal of clinical investigation · 2010Article
- Quantitative trait loci associated with murine central corneal thickness.Physiological genomics · 2010Article
- The path to open-angle glaucoma gene discovery: endophenotypic status of intraocular pressure, cup-to-disc ratio, and central corneal thickness.Investigative ophthalmology & visual science · 2010Article
- Genome-wide linkage analysis of multiple metabolic factors: evidence of genetic heterogeneity.Obesity (Silver Spring, Md.) · 2010Article
- Repeated measures of intraocular pressure result in higher heritability and greater power in genetic linkage studies.Investigative ophthalmology & visual science · 2009Article
- Lifestyle, nutrition, and glaucoma.Journal of glaucoma · 2009Review
- Progress toward personalized medicine for glaucoma.Expert review of ophthalmology · 2009Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo identify genetic loci that control intraocular pressure (IOP).
methodsWe performed a genomewide scan of IOP, using 486 pedigrees ascertained through a population-based cohort, the Beaver Dam Eye Study. Linkage analysis was performed using the modified Haseman-Elston regression models and variance components linkage analysis.
resultsSeven regions of interest were identified on chromosomes 2, 5, 6, 7, 12, 15, and 19. The novel linkage region on chromosome 19p had an empirical multipoint P value of 6.1 x 10(-5). Two of the regions (2 and 19) were especially interesting since each has been identified as a potential linkage region for blood pressure.
conclusionsThe results of this genomewide scan provide evidence that a quantitative trait locus may influence elevated IOP and may colocalize with blood pressure loci. These loci may control systemic pressure reflected in the eye and vascular system. CLINICAL RELEVANCE: Glaucoma is a leading cause of blindness in the world, and the identification of genes that contribute to this disease is essential. Elevated IOP is a principal risk factor for primary open-angle glaucoma and an intriguing quantitative trait that may strongly influence the development of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.