ArticleGenes & development2007
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.
Article in Genes & development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 100 citations in OpenAlex.
- The Effect ofLife (Basel, Switzerland) · 2025Article
- Polyploid Formation Through Disrupting Mitotic Sister Chromatid Separation of Spermatogonia based on espl1 Heterozygous Knockout in Fish.Molecular biology and evolution · 2025Article
- Morpho-histological and Transcriptome Analysis Reveal the Unreduced Sperm Formation Mechanism in cdk1-Depletion Zebrafish.Marine biotechnology (New York, N.Y.) · 2024Article
- The molecular mechanisms of human separase regulation.Biochemical Society transactions · 2023Review
- Genetically induced redox stress occurs in a yeast model for Roberts syndrome.G3 (Bethesda, Md.) · 2022Article
- Zebrafish as a Model for Anticancer Nanomedicine Studies.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Genetic Engineering of Zebrafish in Cancer Research.Cancers · 2020Review
- Combined Analysis of DNA Methylome and Transcriptome Reveal Novel Candidate Genes Related to PorcineFrontiers in cellular and infection microbiology · 2020Article
- Modeling Cancer with Flies and Fish.Developmental cell · 2019Review
- Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation.The EMBO journal · 2018Article
- Separase prevents genomic instability by controlling replication fork speed.Nucleic acids research · 2018Article
- Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer.Molecular cancer therapeutics · 2016Article
- Zebrafish: an important tool for liver disease research.Gastroenterology · 2015Review
- A fresh look at zebrafish from the perspective of cancer research.Journal of experimental & clinical cancer research : CR · 2015Review
- Positive and negative regulation of vertebrate separase by Cdk1-cyclin B1 may explain why securin is dispensable.The Journal of biological chemistry · 2015Article
- MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERα)-positive mammary adenocarcinomas.Oncogene · 2014Article
- Zebrafish cancer: the state of the art and the path forward.Nature reviews. Cancer · 2013Review
- p53 mutations associated with aging-related rise in cancer incidence rates.Cell cycle (Georgetown, Tex.) · 2013Article
- Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials.Drug discovery today · 2013Review
- Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development.Molecular cancer research : MCR · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proper chromosome segregation is essential for maintenance of genomic integrity and instability resulting from failure of this process may contribute to cancer. Here, we demonstrate that a mutation in the mitotic regulator separase is responsible for the cell cycle defects seen in the zebrafish mutant, cease&desist (cds). Analysis of cds homozygous mutant embryos reveals high levels of polyploidy and aneuploidy, spindle defects, and a mitotic exit delay. Carcinogenesis studies demonstrated that cds heterozygous adults have a shift in tumor spectrum with an eightfold increase in the percentage of fish bearing epithelial tumors, indicating that separase is a tumor suppressor gene in vertebrates. These data strongly support a conserved cross-species role for mitotic checkpoint genes in genetic stability and epithelial carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.