ArticleInfection and immunity2007
Peritoneal lavage cells of Indonesian thin-tail sheep mediate antibody-dependent superoxide radical cytotoxicity in vitro against newly excysted juvenile Fasciola gigantica but not juvenile Fasciola hepatica.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 78 citations in OpenAlex.
- Vaccination of buffaloes with Fasciola gigantica recombinant glutathione S-transferase and fatty acid binding protein.Parasitology research · 2012Trial
- Fasciola hepatica soluble antigens (FhAg) induce ovine PMN innate immune reactions and NET formation in vitro and in vivo.Veterinary research · 2023Article
- Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development.Frontiers in veterinary science · 2023Review
- Two Distinct Superoxidase Dismutases (SOD) Secreted by the Helminth ParasiteAntioxidants (Basel, Switzerland) · 2022Article
- Bovine Natural Antibody Relationships to Specific Antibodies andVeterinary sciences · 2022Article
- Evaluation of Immunogenicity and Efficacy ofVaccines · 2021Article
- Current Status for Controlling the Overlooked Caprine Fasciolosis.Animals : an open access journal from MDPI · 2021Review
- Trematode Proteomics: Recent Advances and Future Directions.Pathogens (Basel, Switzerland) · 2021Review
- Timing of Transcriptomic Peripheral Blood Mononuclear Cell Responses of Sheep toFrontiers in immunology · 2021Article
- A Vaccine Based on Kunitz-Type Molecule Confers Protection AgainstFrontiers in immunology · 2020Article
- Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection.Parasites & vectors · 2018Article
- Fasciola and fasciolosis in ruminants in Europe: Identifying research needs.Transboundary and emerging diseases · 2018Review
- Infection by the Helminth ParasiteMolecular & cellular proteomics : MCP · 2018Article
- Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells.Frontiers in immunology · 2018Review
- Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica.Scientific reports · 2017Article
- Heme-Oxygenase-1 Expression Contributes to the Immunoregulation Induced byFrontiers in immunology · 2017Article
- A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes.PLoS pathogens · 2016Article
- A mucin-like peptide from Fasciola hepatica induces parasite-specific Th1-type cell immunity.Parasitology research · 2016Article
- Fasciola hepatica vaccine: we may not be there yet but we're on the right road.Veterinary parasitology · 2015Article
- Exploring the antigenic features of Fasciola hepatica rediae (Trematoda: Digenea) through the evaluation of different antigenic candidates for further monoclonal antibody generation.Parasitology research · 2014Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indonesian thin-tail (ITT) sheep resist infection by Fasciola gigantica by an immunological mechanism within 2 to 4 weeks of infection yet are susceptible to F. hepatica infection. Studies of ITT sheep show that little liver damage occurs following F. gigantica infection, suggesting that the invading parasites are killed within the peritoneum or shortly after reaching the liver. We investigated whether cells isolated from the peritoneums of ITT sheep could kill newly excysted juvenile F. gigantica in vitro and act as a potential mechanism of resistance against F. gigantica infection. Peritoneal cells from F. gigantica-infected sheep, rich in macrophages and eosinophils, mediated antibody-dependent cytotoxicity against juvenile F. gigantica in vitro. Cytotoxicity was dependent on contact between the parasite and effector cells. Isolated mammary gland eosinophils of F. gigantica-infected sheep, or resident peritoneal monocytes/macrophages from uninfected sheep, also killed the juvenile parasites in vitro. By using inhibitors, we show that the molecular mechanism of killing in these assays was dependent on the production of superoxide radicals by macrophages and eosinophils. In contrast, this cytotoxic mechanism was ineffective against juvenile F. hepatica parasites in vitro. Analysis of superoxide dismutase activity and mRNA levels showed that activity and gene expression were higher in F. hepatica than in F. gigantica, suggesting a possible role for this enzyme in the resistance of F. hepatica to superoxide-mediated killing. We suggest that ovine macrophages and eosinophils, acting in concert with a specific antibody, may be important effector cells involved in the resistance of ITT sheep to F. gigantica.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.