ArticleJournal of neurology, neurosurgery, and psychiatry2007
Dynamic changes in corticospinal tracts after stroke detected by fibretracking.
Article in Journal of neurology, neurosurgery, and psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Research hotspots and trends in the application of diffusion tensor imaging in ischemic stroke: a bibliometric analysis (2003-2024).Frontiers in neurology · 2025Pooled it
- Corticospinal tract change during motor recovery in patients with medulla infarct: a diffusion tensor imaging study.BioMed research international · 2014Trial
- Wallerian degeneration in the corticospinal tract evaluated by diffusion tensor imaging correlates with motor deficit 30 days after middle cerebral artery ischemic stroke.AJNR. American journal of neuroradiology · 2010Trial
- The relationship between corticospinal tract and the affected lower limb function and walking ability in subacute stroke patients: a preliminary study.Journal of physical therapy science · 2026Article
- Neuroengineering approaches assessing structural and functional changes of motor descending pathways in stroke.Progress in biomedical engineering (Bristol, England) · 2025Review
- Histopathological Changes of the Corticospinal Tract Following Hemorrhagic and Ischemic Stroke.Brain sciences · 2025Article
- Stroke-Induced Secondary Neurodegeneration of the Corticospinal Tract-Time Course and Mechanisms Underlying Signal Changes in Conventional and Advanced Magnetic Resonance Imaging.Journal of clinical medicine · 2024Review
- A bibliometric analysis of the top 100 most cited articles on corticospinal tract regeneration from 2004 to 2024.Frontiers in neuroscience · 2024Review
- Neural bases characterizing chronic and severe upper-limb motor deficits after brain lesion.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Diffusion tensor imaging tractography in the one-humped camel (Frontiers in veterinary science · 2023Article
- Clinical Effectiveness of Non-Immersive Virtual Reality Tasks for Post-Stroke Neuro-Rehabilitation of Distal Upper-Extremities: A Case Report.Journal of clinical medicine · 2022Article
- White matter alterations in chronic MDMA use: Evidence from diffusion tensor imaging and neurofilament light chain blood levels.NeuroImage. Clinical · 2022Article
- White matter degeneration revealed by fiber-specific analysis relates to recovery of hand function after stroke.Human brain mapping · 2021Article
- Axonal remodeling of the corticospinal tract during neurological recovery after stroke.Neural regeneration research · 2021Review
- An overview of fractional anisotropy as a reliable quantitative measurement for the corticospinal tract (CST) integrity in correlation with a Fugl-Meyer assessment in stroke rehabilitation.Journal of physical therapy science · 2021Review
- Basal Ganglia versus Peripheral Infarcts: Predictive Value of Early Fiber Alterations.AJNR. American journal of neuroradiology · 2021Article
- Diffusion Tensor Imaging Tractography of White Matter Tracts in the Equine Brain.Frontiers in veterinary science · 2020Article
- Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke.Nature communications · 2019Observational
- Brain networks and their relevance for stroke rehabilitation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Review
- Anatomical accuracy of standard-practice tractography algorithms in the motor system - A histological validation in the squirrel monkey brain.Magnetic resonance imaging · 2019Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe integrity of motor pathways and functional connectivity patterns are important in assessing plastic changes related to successful recovery, to obtain prognostic information and to monitor future therapeutic strategies of stroke patients. We tested the following hypotheses: (1) that changes in axonal integrity along the corticospinal tract after stroke can be detected as a reduction in fractional anisotropy; and (2) that sustained low fractional anisotropy is indicative of axonal loss and therefore is correlated with poor motor outcome, as measured by specific neurological motor scores.
methodsWe developed a segmentation tool based on magnetic resonance diffusion tensor imaging in conjunction with three dimensional fibretracking for longitudinal studies of the corticospinal tract, and used specific neurological motor scores to test the hypotheses in five stroke patients within the first week and 30 and 90 days after the stroke.
resultsReduction in fractional anisotropy within the first weeks after stroke reflected a decline in axonal integrity, leading to Wallerian degeneration, and demonstrated a correlation between the temporal evolution of fractional anisotropy and motor function in patients with poor motor outcome.
conclusionThe study demonstrated the feasibility of fibretracking as a segmentation tool for mapping distal parts of the corticospinal motor pathways and showed that fractional anisotropy in the segmented corticospinal tract is a sensitive measure of structural changes after stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.