ArticleJournal of the Royal Society, Interface2007
Vaccination and the dynamics of immune evasion.
Article in Journal of the Royal Society, Interface, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed.
- The speed of vaccination rollout and the risk of pathogen adaptation.Journal of the Royal Society, Interface · 2025Article
- Eco-evolutionary dynamics of pathogen immune-escape: deriving a population-level phylodynamic curve.Journal of the Royal Society, Interface · 2025Article
- Diagnostic testing and the evolution of detection avoidance by pathogens.Evolution, medicine, and public health · 2024Article
- Effects of epistasis and recombination between vaccine-escape and virulence alleles on the dynamics of pathogen adaptation.Nature ecology & evolution · 2022Article
- Robust models of disease heterogeneity and control, with application to the SARS-CoV-2 epidemic.PLOS global public health · 2022Article
- Mosaic vaccination: How distributing different vaccines across a population could improve epidemic control.Evolution letters · 2021Article
- Self-enforcing regional vaccination agreements.Journal of the Royal Society, Interface · 2016Article
- Mathematical model reveals how regulating the three phases of T-cell response could counteract immune evasion.Immunology · 2015Article
- The evolutionary consequences of alternative types of imperfect vaccines.Journal of mathematical biology · 2014Article
- The Possible Impact of Vaccination for Seasonal Influenza on Emergence of Pandemic Influenza via Reassortment.PloS one · 2014Article
- Impact of viral drift on vaccination dynamics and patterns of seasonal influenza.BMC infectious diseases · 2013Article
- Article
- How is vaccine effectiveness scaled by the transmission dynamics of interacting pathogen strains with cross-protective immunity?PloS one · 2012Article
- Boosting understanding of pertussis outbreaks.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Protocols for sampling viral sequences to study epidemic dynamics.Journal of the Royal Society, Interface · 2010Article
- Why do adaptive immune responses cross-react?Evolutionary applications · 2009Article
- Infection dynamics: from organ to host population.Journal of the Royal Society, Interface · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccines exert strong selective pressures on pathogens, favouring the spread of antigenic variants. We propose a simple mathematical model to investigate the dynamics of a novel pathogenic strain that emerges in a population where a previous strain is maintained at low endemic level by a vaccine. We compare three methods to assess the ability of the novel strain to invade and persist: algebraic rate of invasion; deterministic dynamics; and stochastic dynamics. These three techniques provide complementary predictions on the fate of the system. In particular, we emphasize the importance of stochastic simulations, which account for the possibility of extinctions of either strain. More specifically, our model suggests that the probability of persistence of an invasive strain (i) can be minimized for intermediate levels of vaccine cross-protection (i.e. immune protection against the novel strain) and (ii) is lower if cross-immunity acts through a reduced infectious period rather than through reduced susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.