ArticleArchives of oral biology2007
Immunohistochemical characterization of slow and fast myosin heavy chain composition of muscle fibres in the styloglossus muscle of the human and macaque (Macaca rhesus).
Article in Archives of oral biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Development of a functional sarcopenia model utilizing a microcantilever microphysiological system as a phenotypic disease model.In vitro models · 2026Article
- Primate Swallowing Is Powered by Both Rotation and Contraction of Suprahyoid Muscles.American journal of biological anthropology · 2026Article
- Biomechanical and Cortical Control of Tongue Movements During Chewing and Swallowing.Dysphagia · 2024Review
- Dynamic Musculoskeletal Functional Morphology: Integrating diceCT and XROMM.Anatomical record (Hoboken, N.J. : 2007) · 2018Article
- Absence of morphological and molecular correlates of sarcopenia in the macaque tongue muscle styloglossus.Experimental gerontology · 2016Article
- Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys.Experimental gerontology · 2012Article
- Myosin heavy chain composition of the human genioglossus muscle.Journal of speech, language, and hearing research : JSLHR · 2012Article
- Influence of tongue muscle contraction and transmural pressure on nasopharyngeal geometry in the rat.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Human tongue neuroanatomy: Nerve supply and motor endplates.Clinical anatomy (New York, N.Y.) · 2010Article
- Myosin heavy-chain composition of the human hyoglossus muscle.Dysphagia · 2010Article
- Sarcomeric myosin expression in the tongue body of humans, macaques and rats.Cells, tissues, organs · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveMuscle fibre contractile diversity is thought to be increased by the hybridization of multiple myosin heavy chain (MHC) isoforms in single muscle fibres. Reports of hybrid fibres composed of MHCI and MHCII isoforms in human, but not macaque, tongue muscles, suggest a human adaptation for increased tongue muscle contractile diversity. Here we test whether hybrid fibres composed of MHCI and MHCII are unique to human tongue muscles or are present as well in the macaque.
methodsMHC composition of the macaque and human styloglossus was characterized with antibodies that allowed identification of three muscle fibre phenotypes, a slow phenotype composed of MHCI, a fast phenotype composed of MHCII and a hybrid phenotype composed of MHCI and MHCII.
resultsThe fast phenotype constitutes 68.5% of fibres in the macaque and 43.4% of fibres in the human (P<0.0001). The slow phenotype constitutes 20.2% of fibres in the macaque and 39.3% of fibres in the human (P<0.0001). The hybrid phenotype constitutes 11.2% of fibres in the macaque and 17.3% of fibres in the human (P=0.0002). Macaques and humans do not differ in fiber size (cross-sectional area, diameter). However, measures of fibre size differ by phenotype such that fast>hybrid>slow (P<0.05).
conclusionThese data demonstrate differences in the relative percent of muscle fibre phenotypes in the macaque and human styloglossus but also demonstrate that all three phenotypes are present in both species. These data suggest a similar range of mechanical properties in styloglossus muscle fibres of the macaque and human.
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