ArticleJournal of bacteriology2007
CadC has a global translational effect during acid adaptation in Salmonella enterica serovar Typhimurium.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- An Ultrasound-AssistedFood science & nutrition · 2025Article
- Reversible acetylation of ribosomal protein S1 serves as a smart switch for Salmonella to rapidly adapt to host stress.Nucleic acids research · 2025Article
- Molecular mechanism of proteolytic cleavage-dependent activation of CadC-mediated response to acid in E. coli.Communications biology · 2024Article
- Transmembrane Transcription Regulators Are Widespread in Bacteria and Archaea.Microbiology spectrum · 2023Article
- Investigation of the polyamine biosynthetic and transport capability ofMicrobiology (Reading, England) · 2021Article
- Acid resistance system CadBA is implicated in acid tolerance and biofilm formation and is identified as a new virulence factor of Edwardsiella tarda.Veterinary research · 2021Article
- Vibrio parahaemolyticus CadC regulates acid tolerance response to enhance bacterial motility and cytotoxicity.Journal of fish diseases · 2021Article
- Taxonomic and Functional Shifts in the Sprout Spent Irrigation Water Microbiome in Response toApplied and environmental microbiology · 2021Article
- The CRISPR-Cas System Is Involved in OmpR Genetic Regulation for Outer Membrane Protein Synthesis inFrontiers in microbiology · 2021Article
- Extensive Chemometric Investigations of Distinctive Patterns and Levels of Biogenic Amines in Fermented Foods: Human Health Implications.Foods (Basel, Switzerland) · 2020Article
- Molecular design of a signaling system influences noise in protein abundance under acid stress in different γ-Proteobacteria.Journal of bacteriology · 2020Article
- A Membrane-Bound Transcription Factor is Proteolytically Regulated by the AAA+ Protease FtsH in Staphylococcus aureus.Journal of bacteriology · 2020Article
- Direct interaction between the transcription factors CadC and OmpR involved in the acid stress response of Salmonella enterica.Journal of microbiology (Seoul, Korea) · 2017Article
- A wide diversity of bacteria from the human gut produces and degrades biogenic amines.Microbial ecology in health and disease · 2017Article
- Global transcriptome and mutagenic analyses of the acid tolerance response of Salmonella enterica serovar Typhimurium.Applied and environmental microbiology · 2015Article
- Spermidine biosynthesis and transport modulate pneumococcal autolysis.Journal of bacteriology · 2014Article
- The global response regulator ExpA controls virulence gene expression through RsmA-mediated and RsmA-independent pathways in Pectobacterium wasabiae SCC3193.Applied and environmental microbiology · 2014Article
- RaoN, a small RNA encoded within Salmonella pathogenicity island-11, confers resistance to macrophage-induced stress.Microbiology (Reading, England) · 2013Article
- Metabolic Regulation of a Bacterial Cell System with Emphasis on Escherichia coli Metabolism.ISRN biochemistry · 2013Review
- Gene expression analysis of Salmonella enterica Enteritidis Nal(R) and Salmonella enterica Kentucky 3795 exposed to HCl and acetic acid in rich medium.Foodborne pathogens and disease · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Salmonella enterica serovar Typhimurium, the membrane-localized CadC is a transcriptional activator of the cadBA operon, which contributes to the acid tolerance response. Unlike in Escherichia coli, in which transcription of cadC is constitutive, in S. enterica serovar Typhimurium cadC expression is induced by low pH and lysine. Inactivation of cadC suppresses the acid-sensitive phenotype of a cadA mutation, suggesting the existence of other CadC-dependent genes in addition to the cadBA operon. Using a proteomic approach, we identified 8 of the putative CadC-induced proteins and 15 of the putative CadC-repressed proteins. The former include porin proteins OmpC and OmpF. The latter include proteins involved in glycolysis, energy production, and stress tolerance. To better understand the altered levels of OmpC and OmpF, we compared expression of ompR in S. enterica serovar Typhimurium wild-type and cadC mutant strains and determined that CadC exerted a negative influence on ompR transcription. Taken together, our findings strongly suggest that CadC may be a global regulator involved in the OmpR regulatory system during acid adaptation.
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