ArticleProceedings of the National Academy of Sciences of the United States of America2007
Role of SUMO in the dynamics of telomere maintenance in fission yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- The fission yeast SUMO-targeted ubiquitin ligase Slx8 functionally associates with clustered centromeres and the silent mating-type region at the nuclear periphery.Biology open · 2024Article
- Review
- SUMO1 Deficiency Exacerbates Neurological and Cardiac Dysfunction after Intracerebral Hemorrhage in Aged Mice.Translational stroke research · 2021Article
- Molecular Aging Markers in Patients with Klinefelter Syndrome.Aging and disease · 2020Article
- The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.Science advances · 2018Article
- Interplay between Top1 and Mms21/Nse2 mediated sumoylation in stable maintenance of long chromosomes.Current genetics · 2017Article
- SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion.PLoS genetics · 2017Article
- Solving the Telomere Replication Problem.Genes · 2017Review
- Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.PLoS genetics · 2016Article
- Pli1(PIAS1) SUMO ligase protected by the nuclear pore-associated SUMO protease Ulp1SENP1/2.The Journal of biological chemistry · 2015Article
- Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease.Scientific reports · 2014Article
- Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.EMBO reports · 2014Article
- SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- End-joining inhibition at telomeres requires the translocase and polySUMO-dependent ubiquitin ligase Uls1.The EMBO journal · 2013Article
- SUMO: a multifaceted modifier of chromatin structure and function.Developmental cell · 2013Review
- Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.PloS one · 2013Article
- Article
- Local and global functions of Timeless and Tipin in replication fork protection.Cell cycle (Georgetown, Tex.) · 2012Review
- SUMO Wrestles with Recombination.Biomolecules · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sheltering of chromosome ends from illegitimate DNA repair reactions and telomere length homeostasis are critical for preserving genomic integrity. Growing evidence implicates covalent protein modification by SUMO (small ubiquitin-like modifier) (sumoylation) in the regulation of numerous DNA transactions, including DNA repair and transcription, as well as heterochromatin formation and maintenance. We have recently shown that fission yeast Pli1p is a SUMO E3 ligase and that pli1 mutants, which are impaired for global sumoylation, are viable, but exhibit de-regulated homologous recombination and marked defects in chromosome segregation and centromeric silencing, as well as a consistent increase in telomere length. In this work, we explore the mechanisms underlying sumoylation-dependent telomere maintenance. We show that Pli1p, but not the related Nse2p, is the principal SUMO E3 ligase enzyme involved. Using both a pli1 mutation and a physiological "knockdown" of sumoylation, achieved by inducible expression of a dominant negative form of the conjugating enzyme Ubc9p, we further show that telomere lengthening induced by lack of sumoylation is not due to unscheduled telomere-telomere recombination. Instead, sumoylation increases telomerase activity, therefore suggesting that this modification controls the activity of a positive or negative regulator of telomerase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.