ArticleBiophysical journal2007
Structure-based kinetic models of modular signaling protein function: focus on Shp2.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways.International journal of molecular sciences · 2024Review
- Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity.The Journal of cell biology · 2022Article
- Understanding the Dynamics of T-Cell Activation in Health and Disease Through the Lens of Computational Modeling.JCO clinical cancer informatics · 2019Review
- Evaluation of Parallel Tempering to Accelerate Bayesian Parameter Estimation in Systems Biology.Proceedings. Euromicro International Conference on Parallel, Distributed, and Network-based Processing · 2018Article
- Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling.PloS one · 2018Article
- A multiscale modeling study of particle size effects on the tissue penetration efficacy of drug-delivery nanoparticles.BMC systems biology · 2017Article
- Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1.Science advances · 2017Article
- Topological and kinetic determinants of the modal matrices of dynamic models of metabolism.PloS one · 2017Article
- Shp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury.Molecular and cellular biology · 2016Article
- Phosphatase specificity and pathway insulation in signaling networks.Biophysical journal · 2015Article
- Analytical reduction of combinatorial complexity arising from multiple protein modification sites.Journal of the Royal Society, Interface · 2015Article
- Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development.Molecular neurobiology · 2014Review
- Modeling formalisms in Systems Biology.AMB Express · 2011Article
- Guidelines for visualizing and annotating rule-based models.Molecular bioSystems · 2011Article
- Hierarchical graphs for rule-based modeling of biochemical systems.BMC bioinformatics · 2011Article
- RuleMonkey: software for stochastic simulation of rule-based models.BMC bioinformatics · 2010Article
- Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth.The Journal of biological chemistry · 2010Article
- A bipolar clamp mechanism for activation of Jak-family protein tyrosine kinases.PLoS computational biology · 2009Article
- Complexity and modularity of intracellular networks: a systematic approach for modelling and simulation.IET systems biology · 2008Article
- Domain-oriented reduction of rule-based network models.IET systems biology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We present here a computational, rule-based model to study the function of the SH2 domain-containing protein tyrosine phosphatase, Shp2, in intracellular signal transduction. The two SH2 domains of Shp2 differentially regulate the enzymatic activity by a well-characterized mechanism, but they also affect the targeting of Shp2 to signaling receptors in cells. Our kinetic model integrates these potentially competing effects by considering the intra- and intermolecular interactions of the Shp2 SH2 domains and catalytic site as well as the effect of Shp2 phosphorylation. Even for the isolated Shp2/receptor system, which may seem simple by certain standards, we find that the network of possible binding and phosphorylation states is composed of over 1000 members. To our knowledge, this is the first kinetic model to fully consider the modular, multifunctional structure of a signaling protein, and the computational approach should be generally applicable to other complex intermolecular interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.