ArticleInternational journal of radiation oncology, biology, physics2007
An evaluation of the variability of tumor-shape definition derived by experienced observers from CT images of supraglottic carcinomas (ACRIN protocol 6658).
Article in International journal of radiation oncology, biology, physics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy: A systematic review and meta-analysis.Head & neck · 2021Pooled it
- Interobserver variation in parotid gland delineation: a study of its impact on intensity-modulated radiotherapy solutions with a systematic review of the literature.The British journal of radiology · 2012Pooled it
- Multimodality imaging with CT, MR and FDG-PET for radiotherapy target volume delineation in oropharyngeal squamous cell carcinoma.BMC cancer · 2015Trial
- Alterations in anatomic and functional imaging parameters with repeated FDG PET-CT and MRI during radiotherapy for head and neck cancer: a pilot study.BMC cancer · 2015Trial
- Inter-observer variability in radiotherapy contouring with the use of autocontouring software: A systematic review.Clinical and translational radiation oncology · 2026Review
- Head and Neck Tumor Segmentation Using Pre-RT MRI Scans and Cascaded DualUNet.Head and Neck Tumor Segmentation for MR-Guided Applications : First MICCAI Challenge, HNTS-MRG 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 17, 2024, proceedings · 2025Article
- Interobserver Variability in a Spanish Society of Radiation Oncology (SEOR) Head and Neck Course. Is Current Contouring Training Sufficient?Advances in radiation oncology · 2024Article
- Are radiomic signatures ready for incorporation in the clinical pipeline?Translational lung cancer research · 2023Article
- Head and neck radiotherapy quality assurance conference for dedicated review of delineated targets and organs at risk: results of a prospective study.Journal of radiotherapy in practice · 2023Article
- Interobserver variability in organ at risk delineation in head and neck cancer.Radiation oncology (London, England) · 2021Article
- Evaluation of Deep Learning to Augment Image-Guided Radiotherapy for Head and Neck and Prostate Cancers.JAMA network open · 2020Article
- Current Standards for Organ Preservation in Locoregionally Advanced Non-nasopharyngeal Head and Neck Cancer and Evolving Strategies for Favorable-Risk and Platinum-Ineligible Populations.Current treatment options in oncology · 2019Review
- Improved detection rates and treatment planning of head and neck cancer using dual-layer spectral CT.European radiology · 2018Article
- Assessment of the Impact of Deformable Registration of Diagnostic MRI to Planning CT on GTV Delineation for Radiotherapy for Oropharyngeal Carcinoma in Routine Clinical Practice.Healthcare (Basel, Switzerland) · 2018Article
- Evaluation of diffusion weighted imaging for tumor delineation in head-and-neck radiotherapy by comparison with automatically segmentedPhysics and imaging in radiation oncology · 2018Article
- Metabolic tumor volume of primary tumor predicts survival better than T classification in the larynx preservation approach.Cancer science · 2017Article
- Oesophageal cancer: assessment of tumour response to chemoradiotherapy with tridimensional CT.La Radiologia medica · 2015Article
- Importance of tumor volume in supraglottic and glottic laryngeal carcinoma.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2013Article
- Automated Delineation of Lung Tumors from CT Images Using a Single Click Ensemble Segmentation Approach.Pattern recognition · 2013Article
- Radiomics: the process and the challenges.Magnetic resonance imaging · 2012Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
purposeAccurate target definition is considered essential for sophisticated, image-guided radiation therapy; however, relatively little information has been reported that measures our ability to identify the precise shape of targets accurately. We decided to assess the manner in which eight "experts" interpreted the size and shape of tumors based on "real-life" contrast-enhanced computed tomographic (CT) scans. METHODS AND MATERIALS: Four neuroradiologists and four radiation oncologists (the authors) with considerable experience and presumed expertise in treating head-and-neck tumors independently contoured, slice-by-slice, his/her interpretation of the precise gross tumor volume (GTV) on each of 20 sets of CT scans taken from 20 patients who previously were enrolled in Radiation Therapy Oncology Group protocol 91-11.
resultsThe average proportion of overlap (i.e., the degree of agreement) was 0.532 (95% confidence interval 0.457 to 0.606). There was a slight tendency for the proportion of overlap to increase with increasing average GTV.
conclusionsOur work suggests that estimation of tumor shape currently is imprecise, even for experienced physicians. In consequence, there appears to be a practical limit to the current trend of smaller fields and tighter margins.
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