ArticleBehavioural brain research2007
Strychnine and taurine modulation of amygdala-associated anxiety-like behavior is 'state' dependent.
Article in Behavioural brain research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Repeated administration of L-alanine to mice reduces behavioural despair and increases hippocampal mammalian target of rapamycin signalling: Analysis of gender and metabolic effects.Journal of psychopharmacology (Oxford, England) · 2025Article
- Article
- Taurine Suppression of Central Amygdala GABAergic Inhibitory Signaling via Glycine Receptors Is Disrupted in Alcohol Dependence.Alcoholism, clinical and experimental research · 2020Article
- Anxiolytic Action of Taurine via Intranasal Administration in Mice.Biomolecules & therapeutics · 2019Article
- Anxiety-like behavior and whole-body cortisol responses to components of energy drinks in zebrafish (PeerJ · 2019Article
- Ethanol-induced anxiolysis and neuronal activation in the amygdala and bed nucleus of the stria terminalis.Alcohol (Fayetteville, N.Y.) · 2016Article
- Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain.Journal of medicinal chemistry · 2015Article
- Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.Brain and behavior · 2014Article
- Pharmacological evaluation of total alkaloids from nux vomica: effect of reducing strychnine contents.Molecules (Basel, Switzerland) · 2014Article
- Lateral/basolateral amygdala serotonin type-2 receptors modulate operant self-administration of a sweetened ethanol solution via inhibition of principal neuron activity.Frontiers in integrative neuroscience · 2014Article
- Effect of β3 adrenoceptor activation in the basolateral amygdala on ethanol seeking behaviors.Psychopharmacology · 2014Article
- Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex.The Journal of physiology · 2012Article
- Presynaptic facilitation of glutamate release in the basolateral amygdala: a mechanism for the anxiogenic and seizurogenic function of GluK1 receptors.Neuroscience · 2012Article
- Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit.The Journal of pharmacology and experimental therapeutics · 2012Article
- Article
- Use of the light-dark box to compare the anxiety-related behavior of virgin and postpartum female rats.Pharmacology, biochemistry, and behavior · 2011Article
- Lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the anxiolytic effects of beta 3 adrenoceptor activation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Glutamate plasticity in the drunken amygdala: the making of an anxious synapse.International review of neurobiology · 2010Review
- Early social isolation in male Long-Evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self-administration.Alcoholism, clinical and experimental research · 2009Article
- Ethanol inhibition of kainate receptor-mediated excitatory neurotransmission in the rat basolateral nucleus of the amygdala.Neuropharmacology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Strychnine-sensitive glycine receptors are expressed in many adult forebrain regions, yet the biological function of these receptors outside the spinal cord/brainstem is poorly understood. We have recently shown that rat lateral/basolateral amygdala neurons express strychnine-sensitive glycine-gated currents whose pharmacological and molecular characteristics are consistent with those established for classic ligand-gated chloride channels. The current studies were undertaken to establish the behavioral role, if any, of these strychnine-sensitive glycine receptors. Adult Long-Evans male rats were implanted with guide cannulae targeted at the lateral amygdala and were microinjected with standard artificial cerebrospinal fluid with or without various doses of strychnine or taurine. Anxiety-like behaviors were assessed with the elevated plus maze or the light/dark box. In the elevated plus maze, strychnine decreased closed-arm time and increased open-arm time, suggestive of an anxiolytic effect. Similarly, strychnine produced a modest anxiolytic effect in the light/dark box. Post hoc analysis of 'open-arm' time and 'light-side' time indicated that aCSF-treated animals were distributed into two apparent groups that displayed either high or low amounts of anxiety-like behavior in a given apparatus. Surprisingly, the pharmacological effects of both strychnine and taurine in these assays were dependent upon a given animal's behavioral phenotype. Together, these findings are significant because they suggest that the basal 'emotional state' of the animal could influence the behavioral outcome associated with drug application directly into the lateral/basolateral amygdala. Furthermore, our findings also suggest that compounds acting at amygdala strychnine-sensitive glycine receptors may actively modulate this basal anxiety-like state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.