ArticleBrain research2007
Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines.
Article in Brain research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.
- Glutamatergic abnormalities of the thalamus in schizophrenia: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2008Pooled it
- Specific behaviors during auditory fear conditioning and postsynaptic expression of AMPA receptors in the basolateral amygdala predict interindividual differences in fear generalization in male rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Sex-specific divergent maturational trajectories in the postnatal rat basolateral amygdala.iScience · 2022Article
- Optogenetic study of central medial and paraventricular thalamic projections to the basolateral amygdala.Journal of neurophysiology · 2021Article
- Fear Memory Retrieval Is Associated With a Reduction in AMPA Receptor Density at Thalamic to Amygdala Intercalated Cell Synapses.Frontiers in synaptic neuroscience · 2021Article
- Diverse glutamatergic inputs target spines expressing M1 muscarinic receptors in the basolateral amygdala: An ultrastructural analysis.Brain research · 2019Article
- Evaluation of medial division of the medial geniculate (MGM) and posterior intralaminar nucleus (PIN) inputs to the rat auditory cortex, amygdala, and striatum.The Journal of comparative neurology · 2019Article
- Midline thalamic inputs to the amygdala: Ultrastructure and synaptic targets.The Journal of comparative neurology · 2019Article
- Remembering Mechanosensitivity of NMDA Receptors.Frontiers in cellular neuroscience · 2019Review
- Sex- and Estrus-Dependent Differences in Rat Basolateral Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Input from the medial geniculate nucleus modulates amygdala encoding of fear memory discrimination.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- The Role of Actin Cytoskeleton in Memory Formation in Amygdala.Frontiers in molecular neuroscience · 2016Review
- The Membrane Proximal Region of AMPA Receptors in Lateral Amygdala is Essential for Fear Memory Formation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Qualitatively different effect of repeated stress during adolescence on principal neuron morphology across lateral and basal nuclei of the rat amygdala.Neuroscience · 2015Article
- Adolescent social isolation enhances the plasmalemmal density of NMDA NR1 subunits in dendritic spines of principal neurons in the basolateral amygdala of adult mice.Neuroscience · 2014Article
- Repeated restraint stress exerts different impact on structure of neurons in the lateral and basal nuclei of the amygdala.Neuroscience · 2013Article
- Effects of repeated stress on excitatory drive of basal amygdala neurons in vivo.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine.Psychopharmacology · 2013Article
- Neural and cellular mechanisms of fear and extinction memory formation.Neuroscience and biobehavioral reviews · 2012Review
- Unraveling glutamate-opioid receptor interactions using high-resolution electron microscopy: implications for addiction-related processes.Experimental neurology · 2011Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Synapses onto dendritic spines in the lateral amygdala formed by afferents from the auditory thalamus represent a site of plasticity in Pavlovian fear conditioning. Previous work has demonstrated that thalamic afferents synapse onto LA spines expressing glutamate receptor (GluR) subunits, but the GluR subunit distribution at the synapse and within the cytoplasm has not been characterized. Therefore, we performed a quantitative analysis for alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunits GluR2 and GluR3 and N-methyl-D-aspartate (NMDA) receptor subunits NR1 and NR2B by combining anterograde labeling of thalamo-amygdaloid afferents with postembedding immunoelectron microscopy for the GluRs in adult rats. A high percentage of thalamo-amygdaloid spines was immunoreactive for GluR2 (80%), GluR3 (83%), and NR1 (83%), while a smaller proportion of spines expressed NR2B (59%). To compare across the various subunits, the cytoplasmic to synaptic ratios of GluRs were measured within thalamo-amygdaloid spines. Analyses revealed that the cytoplasmic pool of GluR2 receptors was twice as large compared to the GluR3, NR1, and NR2B subunits. Our data also show that in the adult brain, the NR2B subunit is expressed in the majority of in thalamo-amygdaloid spines and that within these spines, the various GluRs are differentially distributed between synaptic and non-synaptic sites. The prevalence of the NR2B subunit in thalamo-amygdaloid spines provides morphological evidence supporting its role in the fear conditioning circuit while the differential distribution of the GluR subtypes may reflect distinct roles for their involvement in this circuitry and synaptic plasticity.
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