ArticleHuman immunology2007
HLA-G is found in lipid rafts and can act as a signaling molecule.
Article in Human immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Reverse Signaling by MHC-I Molecules in Immune and Non-Immune Cell Types.Frontiers in immunology · 2020Review
- HLA class Ib in pregnancy and pregnancy-related disorders.Immunogenetics · 2017Review
- Association of HLA-A and Non-Classical HLA Class I Alleles.PloS one · 2016Article
- Down-regulation of HLA-G Attenuates Cleavage Rate in Human Triploid Embryos.Journal of reproduction & infertility · 2011Article
- The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells.Cellular and molecular life sciences : CMLS · 2011Review
- Expression of major histocompatibility complex class I proteins and their antigen processing chaperones in mouse embryonic stem cells from fertilized and parthenogenetic embryos.Tissue antigens · 2008Article
- The role of tapasin in MHC class I protein trafficking in embryos and T cells.Journal of reproductive immunology · 2008Article
- MicroRNA expression in preimplantation mouse embryos from Ped gene positive compared to Ped gene negative mice.Journal of assisted reproduction and genetics · 2008Article
- Preimplantation embryo development (Ped) gene copy number varies from 0 to 85 in a population of wild mice identified as Mus musculus domesticus.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Activation of T cells by cross-linking Qa-2, the ped gene product, requires Fyn.American journal of reproductive immunology (New York, N.Y. : 1989) · 2007Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
HLA-G protein is the functional homolog of Qa-2, the product of the mouse preimplantation embryo development (Ped) gene. Embryos expressing Qa-2 on the cell surface exhibit a faster rate of preimplantation cleavage and preferential survival in utero compared with Qa-2-negative embryos. Qa-2 is glycosylphosphatidylinositol (GPI) linked in the cell membrane. As a result, Qa-2 proteins cluster in cholesterol- and sphingolipid-rich lipid raft microdomains in the cell membrane and can signal via raft-associated intracellular signaling molecules. Using T cells as a model system, cross-linking of Qa-2 on the cell membrane has been shown to induce proliferation of resting cells. HLA-G, like Qa-2, lacks a cytoplasmic domain capable of transducing signals from the cell surface to the nucleus, but unlike Qa-2, HLA-G has a short six-amino acid cytoplasmic tail rather than a GPI anchor. To test whether HLA-G, like Qa-2, is located in lipid rafts and can act as a signaling molecule, we used an HLA-G transgenic mouse system. T cells were isolated and tested for HLA-G expression by immunofluorescence and for localization of HLA-G in lipid rafts by immunofluorescence and Western blotting. Next, the T cells were cross-linked with anti-HLA-G antibody to test for induction of proliferation. Our novel results show that HLA-G, like GPI-linked Qa-2, is present in lipid rafts in the cell membrane and can act as a signaling molecule to induce proliferation of resting T cells.
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