ArticlePLoS genetics2007
A high-resolution map of segmental DNA copy number variation in the mouse genome.
Article in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.
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Who cites it
136 citing papers in PubMed.
- Generation of a Ym1 deficient mouse utilising CRISPR-Cas9 in CB6 embryos.Transgenic research · 2025Article
- Towards the detection of copy number variation from single sperm sequencing in cattle.BMC genomics · 2022Article
- Genome-Wide Assessment Characteristics of Genes Overlapping Copy Number Variation Regions in Duroc Purebred Population.Frontiers in genetics · 2021Article
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Whole genome resequencing of the Iranian native dogs and wolves to unravel variome during dog domestication.BMC genomics · 2020Article
- The Genome of C57BL/6J "Eve", the Mother of the Laboratory Mouse Genome Reference Strain.G3 (Bethesda, Md.) · 2019Article
- Finding invisible quantitative trait loci with missing data.Plant biotechnology journal · 2018Article
- Genome-wide analysis reveals differential selection involved with copy number variation in diverse Chinese Cattle.Scientific reports · 2017Article
- Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated.eLife · 2017Article
- CNVs into the wild: screening the genomes of conifer trees (Picea spp.) reveals fewer gene copy number variations in hybrids and links to adaptation.BMC genomics · 2017Article
- Whole-genome sequencing reveals mutational landscape underlying phenotypic differences between two widespread Chinese cattle breeds.PloS one · 2017Article
- Loss of maternal ANNEXIN A10 via a 34-kb deleted-type copy number variation is associated with embryonic mortality in Japanese Black cattle.BMC genomics · 2016Article
- Comparative analyses across cattle genders and breeds reveal the pitfalls caused by false positive and lineage-differential copy number variations.Scientific reports · 2016Article
- Copy number variants in the sheep genome detected using multiple approaches.BMC genomics · 2016Article
- Article
- Genome-Wide Detection of CNVs and Their Association with Meat Tenderness in Nelore Cattle.PloS one · 2016Article
- Bovine NK-lysin: Copy number variation and functional diversification.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Copy number variation-based genome wide association study reveals additional variants contributing to meat quality in Swine.Scientific reports · 2015Article
- Divergence patterns of genic copy number variation in natural populations of the house mouse (Mus musculus domesticus) reveal three conserved genes with major population-specific expansions.Genome research · 2015Article
- Genomic copy number variation in Mus musculus.BMC genomics · 2015Article
76 more citing papers are in PubMed but not listed here.
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11 authors.
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Abstract
Submicroscopic (less than 2 Mb) segmental DNA copy number changes are a recently recognized source of genetic variability between individuals. The biological consequences of copy number variants (CNVs) are largely undefined. In some cases, CNVs that cause gene dosage effects have been implicated in phenotypic variation. CNVs have been detected in diverse species, including mice and humans. Published studies in mice have been limited by resolution and strain selection. We chose to study 21 well-characterized inbred mouse strains that are the focus of an international effort to measure, catalog, and disseminate phenotype data. We performed comparative genomic hybridization using long oligomer arrays to characterize CNVs in these strains. This technique increased the resolution of CNV detection by more than an order of magnitude over previous methodologies. The CNVs range in size from 21 to 2,002 kb. Clustering strains by CNV profile recapitulates aspects of the known ancestry of these strains. Most of the CNVs (77.5%) contain annotated genes, and many (47.5%) colocalize with previously mapped segmental duplications in the mouse genome. We demonstrate that this technique can identify copy number differences associated with known polymorphic traits. The phenotype of previously uncharacterized strains can be predicted based on their copy number at these loci. Annotation of CNVs in the mouse genome combined with sequence-based analysis provides an important resource that will help define the genetic basis of complex traits.
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