ArticleBiomacromolecules2007
Multifunctional polyelectrolyte multilayer films: combining mechanical resistance, biodegradability, and bioactivity.
Article in Biomacromolecules, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Recent advances in layer-by-layer assembly scaffolds for co-delivery of bioactive molecules for bone regeneration: an updated review.Journal of translational medicine · 2024Review
- Bioactive Synthetic Polymer-Based Polyelectrolyte LbL Coating Assembly on Surface Treated AZ31-Mg Alloys.Journal of functional biomaterials · 2023Article
- Enhancing the functionality of self-assembled immune signals using chemical crosslinks.Frontiers in immunology · 2023Article
- Article
- Comparative Analysis of the Functional Properties of Films Based on Carrageenans, Chitosan, and Their Polyelectrolyte Complexes.Marine drugs · 2021Article
- Polyelectrolyte Multilayer Films Based on Natural Polymers: From Fundamentals to Bio-Applications.Polymers · 2021Review
- Spin-Coated Polysaccharide-Based Multilayered Freestanding Films with Adhesive and Bioactive Moieties.Molecules (Basel, Switzerland) · 2020Article
- Preventing S. aureus biofilm formation on titanium surfaces by the release of antimicrobial β-peptides from polyelectrolyte multilayers.Acta biomaterialia · 2019Article
- Relevance and Recent Developments of Chitosan in Peripheral Nerve Surgery.Frontiers in cellular neuroscience · 2019Review
- Article
- Binding Mechanism of the Model Charged Dye Carboxyfluorescein to Hyaluronan/Polylysine Multilayers.ACS applied materials & interfaces · 2017Article
- Intraluminal Release of an Antifungal β-Peptide Enhances the Antifungal and Anti-Biofilm Activities of Multilayer-Coated Catheters in a Rat Model of Venous Catheter Infection.ACS biomaterials science & engineering · 2016Article
- Tailored freestanding multilayered membranes based on chitosan and alginate.Biomacromolecules · 2014Article
- Nanotemplated polyelectrolyte films as porous biomolecular delivery systems. Application to the growth factor BMP-2.Biomatter · 2014Article
- Article
- Polyelectrolyte multilayer nanoshells with hydrophobic nanodomains for delivery of Paclitaxel.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- In situ Synthesis of Oligonucleotide Arrays on Surfaces Coated with Crosslinked Polymer Multilayers.Chemistry of materials : a publication of the American Chemical Society · 2012Article
- Tissue integration of growth factor-eluting layer-by-layer polyelectrolyte multilayer coated implants.Biomaterials · 2011Article
- Processing and characterization of chitosan microspheres to be used as templates for layer-by-layer assembly.Journal of materials science. Materials in medicine · 2010Article
- Tunable drug loading and release from polypeptide multilayer nanofilms.International journal of nanomedicine · 2009Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Cross-linked polyelectrolyte multilayer films (CL PEM) have an increased rigidity and are mechanically more resistant than native (e.g., uncrosslinked) films. However, they are still biodegradable, which make them interesting candidates for biomedical applications. In this study, CL PEM films have been explored for their multifunctional properties as (i) mechanically resistant, (ii) biodegradable, and (iii) bioactive films. Toward this end, we investigated drug loading into CL chitosan/hyaluronan (CHI/HA) and poly(L-lysine)/hyaluronan (PLL/HA) films by simple diffusion of the drugs. Sodium diclofenac and paclitaxel were chosen as model drugs and were successfully loaded into the films. The effect of varying the number of layers in the (CHI/HA) films as well as the cross-linker concentration on diclofenac loading were studied. Diclofenac was released from the film in about 10 h. Paclitaxel was also found to diffuse within CL films. Its activity was maintained after loading in the CL films, and cellular viability could be reduced by about 55% over 3 days. Such a simple approach may be applied to other types of cross-linked films and to other drugs. These results prove that it is possible to design multifunctional multilayer films that combine mechanical resistance, biodegradability, and bioactivity properties into a single PEM architecture.
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Registered trials
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