ArticleWorld journal of gastroenterology2007
Age-related histomorphologic changes in the canine gastrointestinal tract: a histologic and immunohistologic study.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 33 citations in OpenAlex.
- Life-stage differences in nutrient digestibility and physiological parameters in Sapsaree dogs.Frontiers in veterinary science · 2026Article
- Age-related changes in growth and fecal parameters, nutrient digestibility, hematology, and serum biochemistry of Beagle dogs.Journal of animal science and technology · 2025Article
- Nutrition and Aging in Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- From Chihuahua to Saint-Bernard: how did digestion and microbiota evolve with dog sizes.International journal of biological sciences · 2022Review
- Upregulation of signal transducer and activator of transcription 3 in dogs with chronic inflammatory enteropathies.Journal of veterinary internal medicine · 2021Article
- Immunohistochemical investigation of Foxp3 expression in the intestine in healthy and diseased dogs.Veterinary research · 2012Article
- Comparative gastric morphometry of Muong indigenous and Vietnamese wild pigs.TheScientificWorldJournal · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine the changes in the histomorphology of the gastric, jejunal and colonic wall of dogs due to physiological aging.
methodsFull thickness biopsies were taken from the gastrointestinal tracts of 28 dogs of different ages. The thickness of the different layers of the wall was measured and the numbers of proliferating cells as indicated by immunohistochemical detection of Ki67 were counted.
resultsIn the three excision sites, the thickness of all subepithelial layers increased with rising age. The strongest correlation between age and thickness of the intestinal wall was found in the first 10 years of life and in the jejunum (r = 0.6-0.71 for the deep lamina propria mucosa, the muscularis mucosa, and the circular layer of the tunica muscularis). The number of proliferating cells decreased during aging, with the strongest correlation in the lamina propria mucosa and lamina muscularis mucosa of the jejunum and in the colonic submucosa (r = -0.61 to -0.71). Epithelial proliferation was only weakly correlated to the age.
conclusionThe morphology of the deeper layers and the proliferation of mesenchymal cells of the intestinal wall of healthy dogs are correlated with age. Gastrointestinal epithelial proliferation is only weakly age-correlated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.