ReviewParasitology research2007
The use of Trichuris suis and other helminth therapies to treat Crohn's disease.
Review in Parasitology research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Pooled it
- Review
- Review
- Complete Mitochondrial Genome ofLife (Basel, Switzerland) · 2021Article
- Immunomodulatory effect of Syphacia obvelata in treatment of experimental DSS-induced colitis in mouse model.Scientific reports · 2019Article
- Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice.Scientific reports · 2018Article
- Structural Basis for Carbohydrate Recognition and Anti-inflammatory Modulation by Gastrointestinal Nematode Parasite Toxascaris leonina Galectin.The Journal of biological chemistry · 2016Article
- Nuclear and mitochondrial genes for inferring Trichuris phylogeny.Parasitology research · 2015Article
- Helminthes and insects: maladies or therapies.Parasitology research · 2015Review
- Trichuris colobae n. sp. (Nematoda: Trichuridae), a new species of Trichuris from Colobus guereza kikuyensis.Parasitology research · 2014Article
- Interleukin-13-mediated paneth cell degranulation and antimicrobial peptide release.Journal of innate immunity · 2014Article
- Molecular characterization and phylogeny of whipworm nematodes inferred from DNA sequences of cox1 mtDNA and 18S rDNA.Parasitology research · 2013Article
- Helminthic therapy: improving mucosal barrier function.Trends in parasitology · 2012Review
- Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets.PLoS neglected tropical diseases · 2012Article
- Acquired immune heterogeneity and its sources in human helminth infection.Parasitology · 2011Review
- Article
- Infection of non-encapsulated species of Trichinella ameliorates experimental autoimmune encephalomyelitis involving suppression of Th17 and Th1 response.Parasitology research · 2010Article
- Molecular evolution of Trichuris muris isolated from different Muridae hosts in Europe.Parasitology research · 2010Article
- The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease.Clinical and experimental immunology · 2010Article
- An update on the use of helminths to treat Crohn's and other autoimmunune diseases.Parasitology research · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infections with gastrointestinal (GI) nematodes are prevalent worldwide, despite the fact that anti-helminthic medications are regarded as safe, efficient, and widely available globally. In this review, we highlight the potential therapeutic benefits that may be realized through the clinical use of Trichuris suis and other helminths for Crohn's disease (CD). Long-lived helminthic parasites are remarkable in their ability to down-regulate host immunity, protecting themselves from elimination, and also minimize severe pathological host changes. This review summarizes what is known about the underlying mechanisms that may account for the observed patterns in humans treated with helminths for CD. The Th2 arm of the immune system is emphasized as a component of primary importance in the association between the host immune system and GI nematode infections. Although GI nematode infections in humans cause significant morbidity and mortality, the existence and nature of protective mechanisms these helminths may confer remain largely unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.