ArticlePsychopharmacology2007
Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers.
Article in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Association of COMT Val(108/158)Met genotype and cigarette smoking in pregnant women.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2011Pooled it
- COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers.Genes, brain, and behavior · 2015Trial
- Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy.Journal of neural transmission (Vienna, Austria : 1996) · 2012Trial
- Single Nucleotide Polymorphisms WithinCurrent addiction reports · 2024Article
- Association between the ACE-I/D polymorphism and nicotine dependence amongst patients with lung cancer.Biomedical reports · 2020Article
- Cognitive Effects of Nicotine: Recent Progress.Current neuropharmacology · 2018Review
- Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men.Behavioral and brain functions : BBF · 2017Article
- The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- The lack of association between angiotensin-converting enzyme gene insertion/deletion polymorphism and nicotine dependence in multiple sclerosis.Brain and behavior · 2017Article
- Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse.Advances in pharmacology (San Diego, Calif.) · 2014Review
- COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers.The pharmacogenomics journal · 2013Article
- Impact of COMT Val 108/158 Met and DRD2 Taq1B gene polymorphisms on vulnerability to cigarette smoking of Thai males.Journal of molecular neuroscience : MN · 2013Article
- BDNF Val66Met variant and smoking in a Chinese population.PloS one · 2012Article
- COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making.Scientific reports · 2012Article
- Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Article
- Cognitive effects of nicotine: genetic moderators.Addiction biology · 2010Review
- Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample.Psychiatry · 2009Article
- Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
rationaleCatechol-O-methyltransferase (COMT) is an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, which is important in mediating drug reward such as nicotine in tobacco smoke. Different COMT alleles encode enzyme whose activity varies from three- to fourfold that may affect dopamine levels and alter subjective effects of nicotine. Recent evidence also suggests that a COMT polymorphism may be especially important in determining an individual's predisposition to developing nicotine dependence. SUBJECTS AND
methodsWe studied the COMT Val108Met polymorphism in a male population of 203 current smokers, 66 former smokers, and 102 non-smokers. The age-adjusted odds ratios were estimated by multiple logistic regression models.
resultsThe results showed no significant association of the COMT Val108Met with initiation, persistent smoking, or smoking cessation. However, current smokers with the Met allele had significantly higher Fagerstrom Test for Nicotine Dependence scores (7.5 +/- 2.1 vs 6.8 +/- 1.8, p = 0.018) and started smoking significantly earlier (18.4 +/- 4.9 vs 20.1 +/- 5.9 years, p = 0.036).
conclusionsThese results suggest that the COMT Val108Met polymorphism may not influence smoking status in a Chinese male population but may influence the age at which smoking started and smoking severity among smokers. However, the findings must be regarded as preliminary because of the relatively small sample size and marginal associations and should be replicated in a larger cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.