ArticleDevelopment genes and evolution2007
The xbp-1 gene is essential for development in Drosophila.
Article in Development genes and evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 49 citations in OpenAlex.
- Reciprocal targeting of the unfolded protein response regulator Xbp1 and the DOM-A nucleosome remodeler in Drosophila.Nucleic acids research · 2026Article
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- Developmentally-regulated post-apocrine cell death ofFrontiers in cell and developmental biology · 2026Article
- A modERN resource: identification of Drosophila transcription factor candidate target genes using RNAi.Genetics · 2023Article
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- The transition from vitellogenesis to choriogenesis triggers the downregulation of the UPR sensors IRE1 and PERK and alterations in the ER architecture in the follicle cells of the vector Rhodnius prolixus.Cell and tissue research · 2022Article
- The endoplasmic reticulum unfolded protein response varies depending on the affected region of the tissue but independently from the source of stress.Cell stress & chaperones · 2019Article
- Sialome diversity of ticks revealed by RNAseq of single tick salivary glands.PLoS neglected tropical diseases · 2018Article
- Ire1 supports normal ER differentiation in developing Drosophila photoreceptors.Journal of cell science · 2016Article
- Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster.PloS one · 2016Article
- Endoplasmic reticulum stress in periimplantation embryos.Clinical and experimental reproductive medicine · 2015Review
- Transcriptional regulation of secretory capacity by bZip transcription factors.Frontiers in biology · 2015Article
- The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model.Cell death & disease · 2014Article
- Whole-genome expression analysis in the third instar larval midgut of Drosophila melanogaster.G3 (Bethesda, Md.) · 2014Article
- A new tool in C. elegans reveals changes in secretory protein metabolism in ire-1-deficient animals.Worm · 2014Article
- Article
- The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans.Journal of cell science · 2013Article
- Meigo governs dendrite targeting specificity by modulating ephrin level and N-glycosylation.Nature neuroscience · 2013Article
- A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development.Cell stress & chaperones · 2013Article
- Inositol-requiring enzyme 1α is required for gut development in Xenopus lavies embryos.World journal of gastroenterology · 2013Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report in this paper the characterization of Dxbp-1, the Drosophila homologue of the xpb-1 gene that encodes a "bZIP"-containing transcription factor that plays a key role in the unfolded protein response (UPR), an evolutionarily conserved signalling pathway activated by an overload of misfolded proteins in the endoplasmic reticulum (ER). Dxbp-1 is ubiquitously transcribed, and high levels are found in embryonic salivary glands and in the ovarian follicle cells committed to the synthesis of the respiratory appendages. Loss of function of Dxbp-1 induced a recessive larval lethality, thus, revealing an essential requirement for this gene. The Dxbp-1 transcript was submitted to an "unconventional" splicing that generated a processed Dxbp-1s transcript encoding a DXbp-1 protein isoform, as is the case for yeast, Caenorhabditis elegans and vertebrate hac1/xbp-1 transcripts after UPR activation. However, in the absence of exogenously induced ER stress, the Dxbp-1s transcript was also detectable not only throughout embryonic and larval development but also in adults with a high level of accumulation in the male sexual apparatus and, to a lesser extent, in the salivary glands of the third-instar larvae. Using a Dxbp-1:GFP transgene as an in vivo reporter for Dxbp-1 mRNA unconventional splicing, we confirmed that Dxbp-1 processing took place in the salivary glands of the third-instar larvae. The Dxbp-1 gene appears, thus, to play an essential role during the development of Drosophila, hypothetically by stimulating the folding capacities of the ER in cells committed to intense secretory activities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.