ArticleProceedings of the National Academy of Sciences of the United States of America1991
Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Segmental isotopic labeling of proteins for nuclear magnetic resonance.Methods in enzymology · 2009Article
- Genome-wide analysis and experimentation of plant serine/ threonine/tyrosine-specific protein kinases.Plant molecular biology · 2006Article
- Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks.Nature medicine · 2001Article
- Article
- Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Characterization of the transforming domain of a feline sarcoma virus encoding a fgr-related tyrosine kinase.Archives of virology · 1994Article
- Identification of a cysteine-rich receptor for fibroblast growth factors.Molecular and cellular biology · 1992Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of protein-tyrosine kinases (PTKs; ATP:protein-tyrosine O-phosphotransferase, EC 2.7.1.112) was studied in normal human lung and various tumors by PCR followed by molecular cloning and sequence analysis. Six known PTKs (YES, FGR, LYN, HCK, PDGFB-R, and CSF1-R), as well as two additional members of this enzyme family, were detected in lung. One of the newly discovered sequences appears to represent a group of cytosolic PTKs. The cDNA sequence of the second unknown PTK revealed that it is a fourth member of the fibroblast growth factor receptor family. It was therefore called TKF (tyrosine kinase related to fibroblast growth factor receptor). Among a wide variety of cells and tissues tested, including human lymphocytes and macrophages, TKF was only found expressed in lung. Apart from normal lung, TKF expression could be demonstrated in some tumors of lung origin, but also in malignancies not derived from lung tissues. As fibroblast growth factors are generally involved in a variety of functions such as mitogenesis, angiogenesis, and wound healing, the specific expression of a receptor-related gene in lung only may point to yet another special function of this group of proteins.
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