Evidence map›Paper›PMID 17205314›Full record

ArticleNeuroradiology2007

Reversal of flow during carotid artery stenting: use of the Parodi antiembolism system.

Iris Q Grunwald, Panagiotis Papanagiotou, Tobias Struffert, Maria Politi, Christoph Krick, Bernd F M Romaike, Frank Ahlhelm, Wolfgang Reith

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In one paragraph

Article in Neuroradiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01331473 (PROximal Protection VErsus NON-Protection in Carotid Artery Stenting), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01331473 phase3unknown statusnot on this mapstarted 2011, after this paper: background citation

PROximal Protection VErsus NON-Protection in Carotid Artery Stenting (PROVENON Study) A Randomized Prospective MRI-based Trial.

TypeinterventionalSponsorUniversität des SaarlandesRan2011 to 2014Enrolled220ConditionsCarotid Artery StenosisArmsCarotid Artery Stenting with Proximal Protection, Carotid Artery Stenting without Protection
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Iris Q GrunwaldClinic of Diagnostic and Interventional Neuroradiology, University Hospital of the Saarland, Kirrbergestr., 66421, Homburg, Germany. i.grunwald@web.de
Panagiotis Papanagiotou
Tobias Struffert
Maria Politi
Christoph Krick
Bernd F M Romaike
Frank Ahlhelm
Wolfgang Reith

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo evaluate the flow reversal efficacy of the Parodi antiembolism system (PAES) in the prevention of distal emboli during carotid stenting.

methodsA total of 90 patients were treated for internal carotid artery (ICA) stenosis with a stent device. A PAES device was used in 31 symptomatic and 5 asymptomatic patients (total 36 patients) with ICA stenosis, and 54 patients were stented without any protection device. Diffusion-weighted (DW) imaging was performed before and after stenting.

resultsIn the group without PAES protection, 23 out of 54 patients showed new lesions on DW images after stenting. Of the lesions seen, 147 (2.72 lesions/patient) were in the vessel-dependent area. In the group with protection, 19 out of 36 patients had new lesions, and only 34 (0.94 lesions/patient) were noted in the vessel-dependent area. The number of new lesions in the nondependent vessel area did not differ if a protection system was used (P = 0.671). The use of PAES led to a significant reduction (P = 0.024) in the incidence of the most frequently seen lesions (size <2 mm). The stroke death rate was 3.3% overall, 3.7% in the group without protection device, and 2.7% in the PAES group. There were no permanent neurological deficits after 3 months.

conclusionThe PAES is a safe and effective tool to reduce the incidence of embolic complications during carotid stenting. Older patients and patients with higher grade stenosis seem to profit more.

Indexed as

StentsAgedAngiographyBlood Flow VelocityCarotid StenosisCatheterizationDiffusion Magnetic Resonance ImagingFemaleHumansIntracranial EmbolismMaleRegional Blood FlowStatistics, Nonparametric

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.