ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2007
Increased duration of simulated childbirth injuries results in increased time to recovery.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 54 citations in OpenAlex.
- A Cell-Based Therapeutic Strategy for Stress Urinary Incontinence: Functional and Molecular Evidence from Decidua-Derived Mesenchymal Stromal Cells.International journal of molecular sciences · 2026Article
- Regenerative Medicine Approaches to Stress Urinary Incontinence.Biomimetics (Basel, Switzerland) · 2026Review
- Polymer Casting and Water Immersion-Based Large-Area Graphene Transfer for Flexible Electronics Fabrication.ACS applied materials & interfaces · 2026Article
- Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction.Cell & bioscience · 2023Review
- Long-term effects of muscle-derived stem cell therapy on the regeneration of the urethra of female rats.International urogynecology journal · 2022Article
- Perinatal mesenchymal stromal cells of the human decidua restore continence in rats with stress urinary incontinence induced by simulated birth trauma and regulate senescence of fibroblasts from women with stress urinary incontinence.Frontiers in cell and developmental biology · 2022Article
- Molecular and histomorphological evaluation of female rats' urethral tissues after an innovative trauma model of prolonged vaginal distention: immediate, short-term and long-term effects.International urogynecology journal · 2019Article
- Autologous and heterotopic transplantation of adipose stromal vascular fraction ameliorates stress urinary incontinence in rats with simulated childbirth trauma.Regenerative therapy · 2018Article
- Pelvic muscles' mechanical response to strains in the absence and presence of pregnancy-induced adaptations in a rat model.American journal of obstetrics and gynecology · 2018Article
- Controlled release of insulin-like growth factor 1 enhances urethral sphincter function and histological structure in the treatment of female stress urinary incontinence in a rat model.BJU international · 2018Article
- Cell-based secondary prevention of childbirth-induced pelvic floor trauma.Nature reviews. Urology · 2017Review
- Neuroanatomic and behavioral correlates of urinary dysfunction induced by vaginal distension in rats.American journal of physiology. Renal physiology · 2016Article
- Long-term effects of simulated childbirth injury on function and innervation of the urethra.Neurourology and urodynamics · 2015Article
- Impact of parturition on chemokine homing factor expression in the vaginal distention model of stress urinary incontinence.The Journal of urology · 2013Article
- Stem cell therapy for stress urinary incontinence: a critical review.Stem cells and development · 2012Review
- Pelvic organ distribution of mesenchymal stem cells injected intravenously after simulated childbirth injury in female rats.Obstetrics and gynecology international · 2012Article
- Effects of prolonged vaginal distension and β-aminopropionitrile on urinary continence and urethral structure.Urology · 2011Article
- Vulnerability of continence structures to injury by simulated childbirth.American journal of physiology. Renal physiology · 2011Article
- Animal models of stress urinary incontinence.Handbook of experimental pharmacology · 2011Review
- Pudendal nerve injury reduces urethral outlet resistance in diabetic rats.American journal of physiology. Renal physiology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Stress urinary incontinence (SUI) development is strongly correlated with vaginal childbirth, particularly increased duration of the second stage of labor. However, the mechanisms of pelvic floor injury leading to SUI are largely unknown. The aim of this study was to determine the effects of increased duration of vaginal distension (VD) on voiding cystometry, leak point pressure testing, and histology. Sixty-nine virgin female rats underwent VD with an inflated balloon for either 1 or 4 h, while 33 age-matched rats were sham-VD controls. Conscious cystometry, leak point pressure testing, and histopathology were determined 4 days, 10 days, and 6 wk after VD. The increase in abdominal pressure to leakage (LPP) during leak point pressure testing was significantly decreased in both distension groups 4 days after distension, indicative of short-term decreased urethral resistance. Ten days after VD, LPP was significantly decreased in the 4-h but not the 1-h distension group, indicating that a longer recovery time is needed after longer distension duration. Six weeks after VD, LPP was not significantly different from sham-VD values, indicating a return toward normal urethral resistance. In contrast, 6 wk after VD of either duration, the distended rats had not undergone the same increase in voided volume as the sham-VD group, suggesting that some effects of VD do not resolve within 6 wk. Both VD groups demonstrated histopathological evidence of acute injuries and tissue remodeling. In conclusion, this experiment suggests pressure-induced hypoxia as a possible mechanism of injury in vaginal delivery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.