Evidence map›Paper›PMID 17204567›Full record

SynthesisAnnals of the rheumatic diseases2007

Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis.

Robin Christensen, Else Marie Bartels, Arne Astrup, Henning Bliddal

3 registry-linked trialsAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of the rheumatic diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 233 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
233citing papers in PubMed, 19 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00655941 nacompletednot on this mapstarted 2008, after this paper: background citation

Influence of Weight Loss or Exercise on CARtilage in Obese Knee Osteoarthritis Patients: a Randomized Controlled Trial (CAROT).

TypeinterventionalSponsorHenning BliddalRan2008 to 2010Enrolled192ConditionsOsteoarthritis, Knee, ObesityArmsDietary instruction, Exercise
NCT00938808 nacompletednot on this mapstarted 2009, after this paper: background citation

Long-term Intervention With Weight Loss in Patients With Concomitant Obesity and Knee Osteoarthritis. The LIGHT Study

TypeinterventionalSponsorHenning BliddalRan2009 to 2013Enrolled154ConditionsOsteoarthritis, Knee, ObesityArmsday formula diet
NCT04682171 nacompletednot on this mapstarted 2020, after this paper: background citation

Effects of Low Level Laser Therapy on Knee Pain and Function in Patients With Knee Osteoarthritis

TypeinterventionalSponsorRiphah International UniversityRan2020 to 2021Enrolled44ConditionsKnee OsteoarthritisArmsLow level laser therapy, Conventional Exercise Therapy
3 · Its place in the literature

Who cites it

233 citing papers in PubMed, 19 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Antidepressants for hip and knee osteoarthritis.The Cochrane database of systematic reviews · 2022
    Pooled it
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  13. A systematic review and meta-analysis of the effectiveness of meal replacements for weight loss.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019
    Pooled it
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  16. Surgery for weight loss in adults.The Cochrane database of systematic reviews · 2014
    Pooled it
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  18. Obesity and knee osteoarthritis.Inflammopharmacology · 2012
    Pooled it
  19. Biological aspects of early osteoarthritis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012
    Pooled it
  20. Trial

173 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Robin ChristensenThe Parker Institute, H:S Frederiksberg Hospital, DK-2000 Frederiksberg, and Copenhagen University Library, Denmark.
Else Marie Bartels
Arne Astrup
Henning Bliddal

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review aims to assess by meta-analysis of randomised controlled trials (RCTs) changes in pain and function when overweight patients with knee osteoarthritis (OA) achieve a weight loss. Systematic searches were performed and reference lists from the retrieved trials were searched. RCTs were enclosed in the systematic review if they explicitly stated diagnosis of knee OA and reported a weight change as the only difference in intervention from the control group. Outcome Measures for Arthritis Clinical Trials III outcome variables were considered for analysis. Effect size (ES) was calculated using RevMan, and meta-regression analyses were performed using weighted estimates from the random effects analyses. Among 35 potential trials identified, four RCTs including five intervention/control groups met our inclusion criteria and provided data from 454 patients. Pooled ES for pain and physical disability were 0.20 (95% CI 0 to 0.39) and 0.23 (0.04 to 0.42) at a weight reduction of 6.1 kg (4.7 to 7.6 kg). Meta-regression analysis showed that disability could be significantly improved when weight was reduced over 5.1%, or at the rate of >0.24% reduction per week. Clinical efficacy on pain reduction was present, although not predictable after weight loss. Meta-regression analysis indicated that physical disability of patients with knee OA and overweight diminished after a moderate weight reduction regime. The analysis supported that a weight loss of >5% should be achieved within a 20-week period--that is, 0.25% per week.

Indexed as

Weight LossDisability EvaluationHumansObesityOsteoarthritis, KneePain MeasurementRandomized Controlled Trials as Topic

Identifiers

PMID17204567
PMCPMC1856062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.