ArticleJournal of the American Society for Mass Spectrometry2007
Fragmentation of leucine enkephalin as a function of laser fluence in a MALDI TOF-TOF.
Article in Journal of the American Society for Mass Spectrometry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 23 citations in OpenAlex.
- Real-Time Detection of Urban Atmospheric Micro-Nanoplastics and Their Chemical Mixing State Using Bioaerosol Single-Particle Mass Spectrometry.Environmental science & technology · 2025Article
- Degree of ionization in MALDI of peptides: thermal explanation for the gas-phase ion formation.Journal of the American Society for Mass Spectrometry · 2012Article
- Occurrence of C-terminal residue exclusion in peptide fragmentation by ESI and MALDI tandem mass spectrometry.Journal of the American Society for Mass Spectrometry · 2012Article
- Expansion cooling in the matrix plume is under-recognized in MALDI mass spectrometry.Journal of the American Society for Mass Spectrometry · 2011Article
- Changes in dissociation efficiency and kinetics of peptide ions induced by basic residues and their mechanistic implication.Journal of the American Society for Mass Spectrometry · 2011Article
- A comparative study of in- and post-source decays of peptide and preformed ions in matrix-assisted laser desorption ionization time-of-flight mass spectrometry: effective temperature and matrix effect.Journal of the American Society for Mass Spectrometry · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The effects of laser fluence on ion formation in MALDI were studied using a tandem TOF mass spectrometer with a Nd-YAG laser and alpha-cyano hydrocinnamic acid matrix. Leucine enkephalin ionization and fragmentation were followed as a function of laser fluence ranging from the threshold of ion formation to the maximum available, that is, about 280-930 mJ/mm2. The most notable finding was the appearance of immonium ions at fluence values close to threshold, increasing rapidly and then tapering in intensity with the appearance of typical backbone fragment ions. The data suggest the presence of two distinct environments for ion formation. One is associated with molecular desorption at low values of laser fluence that leads to extensive immonium ion formation. The second becomes dominant at higher fluences, is associated initially with backbone type fragments, but, at the highest values of fluence, progresses to immonium fragments. This second environment is suggestive of ion desorption from large pieces of material ablated from the surface. Arrhenius rate law considerations were used to estimate temperatures associated with the onset of these two processes.
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