ArticleExperimental gerontology2007
Aging and estrogen: modulation of inflammatory responses after injury.
Article in Experimental gerontology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Avenanthramide supplementation attenuates exercise-induced inflammation in postmenopausal women.Nutrition journal · 2014Trial
- Intoxication, inflammaging, and injury: my journey through leukocyte biology.Journal of leukocyte biology · 2026Article
- Association between menopause, postmenopausal hormone therapy and peptic ulcer disease in Taiwanese population.Scientific reports · 2025Article
- Estrogen Treatment Lowers the Risk of Complications in Menopausal Women with Mild Burn Injury.Medicina (Kaunas, Lithuania) · 2025Article
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- Article
- High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting.Biogerontology · 2022Article
- Age and Injury Size Influence the Magnitude of Fecal Dysbiosis in Adult Burn Patients.Journal of burn care & research : official publication of the American Burn Association · 2022Article
- Advanced age heightens hepatic damage in a murine model of scald burn injury.The journal of trauma and acute care surgery · 2021Article
- Article
- Bilateral Olfactory Mucosa Damage Induces the Disappearance of Olfactory Glomerulus and Reduces the Expression of Extrasynaptic α5GABANeurotoxicity research · 2018Article
- Increased Adipocyte Area in Injured Muscle With Aging and Impaired Remodeling in Female Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Effects of low-intensity non-coherent light therapy on the inflammatory process in the calcaneal tendon of ovariectomized rats.Lasers in medical science · 2016Article
- Trauma equals danger--damage control by the immune system.Journal of leukocyte biology · 2012Review
- Rejuvenation of the inflammatory system stimulates fracture repair in aged mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2010Article
- Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling.Journal of neuroinflammation · 2009Article
- Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insult.Free radical biology & medicine · 2009Article
- Aging and animal models of systemic insult: trauma, burn, and sepsis.Shock (Augusta, Ga.) · 2009Review
- Enhanced binding of circulating SLE autoantibodies to catecholestrogen-copper-modified DNA.Molecular and cellular biochemistry · 2008Article
- Innate immunity and aging.Experimental gerontology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Aged subjects have a poor prognosis after traumatic injury and, regardless of the type of injury, they have slower recoveries and suffer more complications than their younger counterparts. The age-dependent responses may be influenced by the hyper-inflammatory state observed in the aged prior to injury, including elevated levels of interleukin-6 (IL-6). Physiological levels of estrogen are beneficial to the immune system, due, in part, to the hormone's ability to attenuate aberrant production of pro-inflammatory cytokines. Using two independent injury models, we have found increased mortality and elevated serum levels of IL-6 in aged mice, when compared to young animals (p<0.05). In parallel studies, groups of aged mice given estrogen (17beta-estradiol) prior to scald burn, had significantly improved survival (p<0.05) and lowered serum IL-6 (p<0.05). Multiple cellular mechanisms may be involved in mediating the beneficial effects of estrogen on inflammatory and immune responses in aged individuals who sustain an injury. These mechanisms are discussed herein.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.