Evidence map›Paper›PMID 17204163›Full record

ArticleGenome biology2007

Clustering of genes into regulons using integrated modeling-COGRIM.

Guang Chen, Shane T Jensen, Christian J Stoeckert

Open access · goldAbstract read
In one paragraph

Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Guang ChenDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ggchen@pcbi.upenn.edu
Shane T Jensen
Christian J Stoeckert
University of Pennsylvania · USHuntsman (United States) · US

Funding

FUNCTIONAL GENOMICS OF THE BETA-CELLU01DK056947 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KAESTNER, KLAUS H. · 2002 to 2007
$10.7M
NIDDK NIH HHS U01 DK056947NIDDK NIH HHS U01-DK56947
6 · The paper itself

Abstract

We present a Bayesian hierarchical model and Gibbs Sampling implementation that integrates gene expression, ChIP binding, and transcription factor motif data in a principled and robust fashion. COGRIM was applied to both unicellular and mammalian organisms under different scenarios of available data. In these applications, we demonstrate the ability to predict gene-transcription factor interactions with reduced numbers of false-positive findings and to make predictions beyond what is obtained when single types of data are considered.

Indexed as

Models, GeneticSoftwareCCAAT-Enhancer-Binding Protein-betaChromatin ImmunoprecipitationCluster AnalysisComputational BiologyDatabases, Nucleic AcidEnhancer Elements, GeneticGene DeletionGene Expression RegulationGene Regulatory NetworksLinear ModelsProtein BindingRegulonSaccharomyces cerevisiaeSerum Response FactorCCAAT-Enhancer-Binding Protein-betaSerum Response FactorTranscription Factors

Identifiers

PMID17204163
PMCPMC1839128
OpenAlexW2097090208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.