ArticleJournal of proteome research2007
Protein expression in a Drosophila model of Parkinson's disease.
Article in Journal of proteome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Untangling the adaptive strategies of thermophilic bacterium Anoxybacillus rupiensis TPH1 under low temperature.Extremophiles : life under extreme conditions · 2024Article
- Article
- Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy.NPJ Parkinson's disease · 2020Article
- Proteome-Scale Mapping of Perturbed Proteostasis in Living Cells.Cold Spring Harbor perspectives in biology · 2020Review
- Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function.Frontiers in cell and developmental biology · 2020Review
- Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology.International journal of molecular sciences · 2019Review
- Integrated Analysis of Proteomic and Transcriptomic Data Highlights Late Fetal Muscle Maturation Process.Molecular & cellular proteomics : MCP · 2018Article
- Cofilin 1 activation prevents the defects in axon elongation and guidance induced by extracellular alpha-synuclein.Scientific reports · 2015Article
- A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies.Parkinson's disease · 2011Article
- Insights into aging through measurements of the Drosophila proteome as a function of temperature.Mechanisms of ageing and development · 2010Article
- Neuroproteomics approaches to decipher neuronal regeneration and degeneration.Molecular & cellular proteomics : MCP · 2010Review
- Chemical measurements in Drosophila.Trends in analytical chemistry : TRAC · 2009Article
- Stable isotope labeling and label-free proteomics of Drosophila parkin null mutants.Journal of proteome research · 2009Article
- {alpha}-synuclein and its A30P mutant affect actin cytoskeletal structure and dynamics.Molecular biology of the cell · 2009Article
- Proteomics in animal models of Alzheimer's and Parkinson's diseases.Ageing research reviews · 2009Review
- Proteome response to the panneural expression of human wild-type alpha-synuclein: a Drosophila model of Parkinson's disease.Journal of proteome research · 2008Article
- Global relationship between the proteome and transcriptome of human skeletal muscle.Journal of proteome research · 2008Article
- Article
- Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.Molecular & cellular proteomics : MCP · 2008Article
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4 authors.
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Abstract
Liquid chromatographies coupled to mass spectrometry and database analysis techniques are used to carry out a large-scale proteome characterization for a Drosophila model of Parkinson's disease. Semiquantitative analysis is performed on A30P alpha-synuclein expressing transgenic Drosophila and a control lacking the gene at presymptomatic, early, and advanced disease stages. Changes in gene expression at the level of the proteome are compared with changes reported from published transcriptome measurements. A summary of the comparison indicates that approximately 44% of transcripts that show changes can also be observed as proteins. However, the patterns of change in protein expression vary substantially compared with the patterns of change observed for corresponding transcripts. In addition, the expression changes of many genes are observed for only transcripts or proteins. Proteome measurements provide evidence for dysregulation of a group of proteins associated with the actin cytoskeleton and mitochondrion at presymptomatic and early disease stages that may presage the development of later symptoms. Overall, the proteome measurements provide a view of gene expression that is highly complementary to the insights obtained from the transcriptome.
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