ArticleDigestive diseases and sciences2006
Influence of Trypanosoma cruzi chronic infection in the depletion of esophageal neurons in Calomys callosus.
Article in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review.Oxidative medicine and cellular longevity · 2022Pooled it
- Paracoccidioides brasiliensis pancreatic destruction in Calomys callosus experimentally infected.BMC microbiology · 2009Article
- Does cyclophosphamide play a protective role against neuronal loss in chronic T. cruzi infection?Digestive diseases and sciences · 2008Article
- Could cyclophosphamide exert a protective role avoiding esophagic neuron loss in Calomys callosus infected with Trypanosoma cruzi?Digestive diseases and sciences · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extent of neuronal loss was studied in this work, in aged female Calomys callosus infected with the MORC-1 strain of Trypanosoma cruzi. Fifteen months after infection, one group of animals was immunosuppressed with cyclophosphamide (CY). Sections of the distal esophagus were collected and stained with cresyl violet. The neuron count was significantly different among groups, with enhanced neuronal loss in the infected group in comparison with the control aged noninfected group. Partial protection against neuronal destruction was observed in animals immunosuppressed with CY. The morphometry of the neuronal body displayed significant alterations concerning area, shape coefficient, and contour index that were statistically increased for the CY-infected group. These results indicate a protective role for CY against neuronal destruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.