ArticleEuropean journal of pediatrics2007
Growth parameters in maternal uniparental disomy 7 and 14.
Article in European journal of pediatrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Maternal-fetal conflict and the timing of birth.Evolution, medicine, and public health · 2025Review
- Anderson's disease/chylomicron retention disease in a Japanese patient with uniparental disomy 7 and a normal SAR1B gene protein coding sequence.Orphanet journal of rare diseases · 2011Article
- The evolutionary biology of child health.Proceedings. Biological sciences · 2011Review
- Colloquium papers: Transfers and transitions: parent-offspring conflict, genomic imprinting, and the evolution of human life history.Proceedings of the National Academy of Sciences of the United States of America · 2010Review
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1 author at 1 institution in 1 country.
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Abstract
introductionGrowth retardation has been reported in most cases of maternal uniparental disomy (UPD) 7 and 14, but has never been evaluated in a systematic approach. In this study, an analysis is presented of the auxological data from the literature at birth and on the occasion of the last evaluation of 34 cases with maternal UPD 7 (21 heterodisomy, 13 isodisomy) and 29 cases with maternal UPD 14 (22 heterodisomy, 7 isodisomy). For maternal UPD 7, statistical analysis revealed that length and weight at birth as well as on the occasion of the last evaluation were strongly below average (-2.94 SD and -2.62 SD, and -3.39 SD and -3.11 SD, respectively), whereas at both evaluations occipitofrontal head circumference (OFC) was only slightly below the average (-1.00 SD and -0.85 SD). For maternal UPD 14 at birth, growth retardation is rather concordant for length, weight, and OFC (-2.78 SD, -2.84 SD, and -1.69 SD). Later in life body mass index (BMI) is above average (1.06 SD) and continuously increasing before and after puberty (-0.58 SD and 2.07 SD).
conclusionGrowth retardation and relative macrocephaly are of prenatal onset and still present in adults with maternal UPD 7. For patients with maternal UPD 14, growth curves for height, BMI and OFC differ strongly. Genomic imprinting might be a major causative factor, but it seems to function differently for maternal UPD 7 and maternal UPD 14.
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