ReviewMolecular imaging and biology
Molecular imaging of brain tumors: a bridge between clinical and molecular medicine?
Review in Molecular imaging and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- A novel brain MRI classification framework integrating tuned single scale retinex and empirical wavelet entropy features.Scientific reports · 2025Article
- Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates.European journal of nuclear medicine and molecular imaging · 2023Article
- State-of-the-Art Imaging in Human Chordoma of the Skull Base.Current radiology reports · 2018Review
- Investigation of platinum nanoparticle properties against U87 glioblastoma multiforme.Archives of medical science : AMS · 2017Article
- Differential diagnosis of posterior fossa brain tumors: Multiple discriminant analysis of Tl-SPECT and FDG-PET.Medicine · 2017Observational
- The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of patients with brain tumor.Archives of medical science : AMS · 2017Article
- Chordoma dedifferentiation after proton beam therapy: a case report and review of the literature.Journal of medical case reports · 2016Review
- Salmonella enterica serovar Enteritidis brain abscess mimicking meningitis after surgery for glioblastoma multiforme: a case report and review of the literature.Journal of medical case reports · 2016Review
- Molecular imaging for stem cell therapy in the brain.Stem cell research & therapy · 2015Article
- Observational
- Spinal molecular imaging by (68) Ga-DOTATATE-positron emission tomography.Journal of craniovertebral junction & spine · 2014Article
- Small-cell lung cancer with voltage-gated calcium channel antibody-positive paraneoplastic limbic encephalitis: a case report.Journal of medical case reports · 2014Article
- Solitary skull metastasis as the first symptom of hepatocellular carcinoma: case report and literature review.Neuropsychiatric disease and treatment · 2014Review
- Stem cell transplantation in neuroscience: the role of molecular imaging.Stem cell reviews and reports · 2012Review
- Molecular imaging of stem cell therapy in brain tumors: a step towards personalized medicine.Archives of medical science : AMS · 2012Article
- Specific biomarkers of receptors, pathways of inhibition and targeted therapies: pre-clinical developments.The British journal of radiology · 2011Review
- Use of radionuclides in cancer research and treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2009Review
- Strategies for molecular imaging dementia and neurodegenerative diseases.Neuropsychiatric disease and treatment · 2008Article
- Hints on new applications of emission tomography and magnetic resonance in neuro-oncology.European journal of nuclear medicine and molecular imaging · 2007Article
- Current molecular imaging of spinal tumors in clinical practice.Molecular medicine (Cambridge, Mass.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the research on cellular changes has shed invaluable light on the pathophysiology and biochemistry of brain tumors, clinical and experimental use of molecular imaging methods is expanding and allows quantitative assessment. The term molecular imaging is defined as the in vivo characterization and measurement of biologic processes at the cellular and molecular level. Molecular imaging sets forth to probe the molecular abnormalities that are the basis of disease rather than to visualize the end effects of these molecular alterations and, therefore, provides different additional biochemical or molecular information about primary brain tumors compared to histological methods "classical" neuroradiological diagnostic studies. Common clinical indications for molecular imaging contain primary brain tumor diagnosis and identification of the metabolically most active brain tumor reactions (differentiation of viable tumor tissue from necrosis), prediction of treatment response by measurement of tumor perfusion, or ischemia. The interesting key question remains not only whether the magnitude of biochemical alterations demonstrated by molecular imaging reveals prognostic value with respect to survival, but also whether it identifies early disease and differentiates benign from malignant lesions. Moreover, an early identification of treatment success or failure by molecular imaging could significantly influence patient management by providing more objective decision criteria for evaluation of specific therapeutic strategies. Specially, as molecular imaging represents a novel technology for visualizing metabolism and signal transduction to gene expression, reporter gene assays are used to trace the location and temporal level of expression of therapeutic and endogenous genes. Molecular imaging probes and drugs are being developed to image the function of targets without disturbing them and in mass amounts to modify the target's function as a drug. Molecular imaging helps to close the gap between in vitro and in vivo integrative biology of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.