ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Developmental changes in CaScientific reports · 2026Article
- Connexin 36-mediated gap junctions contribute to fine odour discrimination and late-phase excitation of mitral cells in the mouse olfactory bulb.The Journal of physiology · 2026Article
- The superficial tufted and mitral cell output neurons of the mouse olfactory bulb have dual roles in insulin sensing.Journal of cell science · 2025Article
- Sister external tufted cells form dynamic intraglomerular ensembles representing odor identity and concentration.iScience · 2025Article
- Modulating the Excitability of Olfactory Output Neurons Affects Whole-Body Metabolism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Development of the mammalian main olfactory bulb.Development (Cambridge, England) · 2022Review
- Cellular and Synaptic Mechanisms That Differentiate Mitral Cells and Superficial Tufted Cells Into Parallel Output Channels in the Olfactory Bulb.Frontiers in cellular neuroscience · 2020Article
- A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1.Scientific reports · 2019Article
- Distinct temporal filters in mitral cells and external tufted cells of the olfactory bulb.The Journal of physiology · 2017Article
- Inhibitory circuits of the mammalian main olfactory bulb.Journal of neurophysiology · 2017Review
- Differences in Glomerular-Layer-Mediated Feedforward Inhibition onto Mitral and Tufted Cells Lead to Distinct Modes of Intensity Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Parallel processing of afferent olfactory sensory information.The Journal of physiology · 2016Article
- The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel.The Journal of physiology · 2016Article
- Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Postnatal development attunes olfactory bulb mitral cells to high-frequency signaling.Journal of neurophysiology · 2015Article
- Metabotropic glutamate receptors promote disinhibition of olfactory bulb glomeruli that scales with input strength.Journal of neurophysiology · 2015Article
- Intraglomerular lateral inhibition promotes spike timing variability in principal neurons of the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Bulbar microcircuit model predicts connectivity and roles of interneurons in odor coding.PloS one · 2015Article
- Presynaptic T-type Ca2+ channels modulate dendrodendritic mitral-mitral and mitral-periglomerular connections in mouse olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Activation of group I metabotropic glutamate receptors enhances persistent sodium current and rhythmic bursting in main olfactory bulb external tufted cells.Journal of neurophysiology · 2014Article
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Authors and funding
2 authors.
Funding
Abstract
Sensory systems often respond to rapid stimuli with high frequency and fidelity, as perhaps best exemplified in the auditory system. Fast synaptic responses are fundamental requirements to achieve this task. The importance of speed is less clear in the olfactory system. Moreover, olfactory bulb output mitral cells respond to a single stimulation of the sensory afferents with unusually long EPSPs, lasting several seconds. We examined the temporal characteristics, developmental regulation, and the mechanism generating these responses in mouse olfactory bulb slices. The slow EPSP appeared at postnatal days 10-11 and was mediated by metabotropic glutamate receptor 1 (mGluR1) and NMDA receptors. mGluR1 contribution was unexpected because its activation usually requires strong, high-frequency stimulation of inputs. However, dendritic release of glutamate from the intraglomerular network caused spillover-mediated recurrent activation of metabotropic glutamate receptors. We suggest that persistent responses in mitral cells amplify the incoming sensory information and, along with asynchronous inputs, drive odor-evoked slow temporal activity in the bulb.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.