ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Taste-evoked responses to sweeteners in the nucleus of the solitary tract differ between C57BL/6ByJ and 129P3/J mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Mapping Fos-immunoreactive neurons activated by intra-oral infusion of quinine, sucrose or water throughout the brain of B6 mice.Brain structure & function · 2026Article
- TRPV1-Lineage Somatosensory Fibers Communicate with Taste Neurons in the Mouse Parabrachial Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Variation in the geneAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Genetics of mouse behavioral and peripheral neural responses to sucrose.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Article
- Two neuronal groups for NaCl with differential taste response properties and topographical distributions in the rat parabrachial nucleus.Physiological reports · 2020Article
- Genetics of Amino Acid Taste and Appetite.Advances in nutrition (Bethesda, Md.) · 2016Review
- Topographic organizations of taste-responsive neurons in the parabrachial nucleus of C57BL/6J mice: An electrophysiological mapping study.Neuroscience · 2016Article
- Bursting by taste-responsive cells in the rodent brain stem.Journal of neurophysiology · 2015Article
- Temperature systematically modifies neural activity for sweet taste.Journal of neurophysiology · 2014Article
- Nucleus of the solitary tract in the C57BL/6J mouse: Subnuclear parcellation, chorda tympani nerve projections, and brainstem connections.The Journal of comparative neurology · 2014Article
- Experience with sugar modifies behavioral but not taste-evoked medullary responses to sweeteners in mice.Chemical senses · 2013Article
- TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to bitter, sweet, and umami taste stimuli.Journal of neurophysiology · 2012Article
- Sweet-bitter and umami-bitter taste interactions in single parabrachial neurons in C57BL/6J mice.Journal of neurophysiology · 2012Article
- Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice.Journal of neurophysiology · 2012Article
- Central representation of postingestive chemosensory cues in mice that lack the ability to taste.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Citric acid and quinine share perceived chemosensory features making oral discrimination difficult in C57BL/6J mice.Chemical senses · 2011Article
- Subnuclear organization of parabrachial efferents to the thalamus, amygdala and lateral hypothalamus in C57BL/6J mice: a quantitative retrograde double labeling study.Neuroscience · 2010Article
- Properties of GABAergic neurons in the rostral solitary tract nucleus in mice.Journal of neurophysiology · 2010Article
- Afferent connections of the parabrachial nucleus in C57BL/6J mice.Neuroscience · 2009Article
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Abstract
C57BL/6ByJ (B6) and 129P3/J (129) mice have different alleles of Tas1r3, which is thought to influence gustatory transduction of sweeteners, but studies have provided conflicting results regarding differences in sweetness perception between these strains. Single-unit taste-evoked activity was measured in the nucleus of the solitary tract (NST) in anesthetized B6 and 129 mice to address this controversy and to provide the first electrophysiological characterization of this nucleus in mice. Neurons had properties similar to those of NST cells in other species, including mean breadth-of-tuning of 0.8 +/- 0.0. There were no strain differences in neural responses at 600 or 900 ms after onset, but, with a 5 s evoked period, responses to the sweeteners sucrose, maltose, acesulfame-K, SC-45647, and D-phenylalanine were significantly larger in B6 relative to 129 mice. The strains did not differ in their mean response to NaSaccharin, but it evoked an across-neuron pattern of activity that was more similar to that of sucrose and less similar to that of NaCl in B6 mice compared with 129 mice. Neurons were classified as sucrose, NaCl, or HCl responsive, with the former more common in B6 than 129 mice. Relative to other neurons, sucrose-responsive cells had delayed but more sustained sweetener responses in both strains. The results suggest that B6 mice perceive some sweeteners as more intense, but NaSaccharin as sweeter and less salty, relative to 129 mice. Furthermore, activity evoked by sweeteners includes a phasic response sent to different NST cells than a later tonic response, and only the latter differs between B6 and 129 mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.