ArticleMolecular biology of the cell2007
Two regions of the tail are necessary for the isoform-specific functions of nonmuscle myosin IIB.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Synaptopodin stress fiber and contractomere at the epithelial junction.The Journal of cell biology · 2022Article
- Different contributions of nonmuscle myosin IIA and IIB to the organization of stress fiber subtypes in fibroblasts.Molecular biology of the cell · 2018Article
- Myosin II isoform co-assembly and differential regulation in mammalian systems.Experimental cell research · 2015Review
- Nonmuscle myosin heavy chain IIb mediates herpes simplex virus 1 entry.Journal of virology · 2015Article
- Article
- Nonmuscle myosin II isoforms coassemble in living cells.Current biology : CB · 2014Article
- High resolution characterization of myosin IIC protein tailpiece and its effect on filament assembly.The Journal of biological chemistry · 2013Article
- Article
- Tetraspanin CD82 inhibits protrusion and retraction in cell movement by attenuating the plasma membrane-dependent actin organization.PloS one · 2012Article
- Germinal center-specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin.The FEBS journal · 2011Article
- Article
- The positively charged region of the myosin IIC non-helical tailpiece promotes filament assembly.The Journal of biological chemistry · 2010Article
- Non-muscle myosin II takes centre stage in cell adhesion and migration.Nature reviews. Molecular cell biology · 2009Review
- Myosin II recruitment during cytokinesis independent of centralspindlin-mediated phosphorylation.The Journal of biological chemistry · 2009Article
- Myosin II tailpiece determines its paracrystal structure, filament assembly properties, and cellular localization.The Journal of biological chemistry · 2009Article
- The C-terminal tail region of nonmuscle myosin II directs isoform-specific distribution in migrating cells.Molecular biology of the cell · 2008Article
- Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells.The Journal of cell biology · 2008Article
- MHC-IIB filament assembly and cellular localization are governed by the rod net charge.PloS one · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To function in the cell, nonmuscle myosin II molecules assemble into filaments through their C-terminal tails. Because myosin II isoforms most likely assemble into homo-filaments in vivo, it seems that some self-recognition mechanisms of individual myosin II isoforms should exist. Exogenous expression of myosin IIB rod fragment is thus expected to prevent the function of myosin IIB specifically. We expected to reveal some self-recognition sites of myosin IIB from the phenotype by expressing appropriate myosin IIB rod fragments. We expressed the C-terminal 305-residue rod fragment of the myosin IIB heavy chain (BRF305) in MRC-5 SV1 TG1 cells. As a result, unstable morphology was observed like MHC-IIB(-/-) fibroblasts. This phenotype was not observed in cells expressing BRF305 mutants: 1) with a defect in assembling, 2) lacking N-terminal 57 residues (N-57), or 3) lacking C-terminal 63 residues (C-63). A myosin IIA rod fragment ARF296 corresponding to BRF305 was not effective. However, the chimeric ARF296, in which the N-57 and C-63 of BRF305 were substituted for the corresponding regions of ARF296, acquired the ability to induce unstable morphology. We propose that the N-57 and C-63 of BRF305 are involved in self-recognition when myosin IIB molecules assemble into homo-filament.
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