ReviewProceedings of the American Thoracic Society2007
Gene expression profiling in human asthma.
Review in Proceedings of the American Thoracic Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Meta-analysis of microarray data to identify potential signature genes and MiRNAs associated with the pathogenesis of asthma.Journal of translational medicine · 2025Pooled it
- Trial
- The Role of Systems Biology in Deciphering Asthma Heterogeneity.Life (Basel, Switzerland) · 2022Review
- Resveratrol in the treatment of asthma based on an animal model.Postepy dermatologii i alergologii · 2022Review
- Derangement of cell cycle markers in peripheral blood mononuclear cells of asthmatic patients as a reliable biomarker for asthma control.Scientific reports · 2021Article
- Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control.American journal of respiratory and critical care medicine · 2017Article
- Analysis on the relevance of asthma susceptibility with the alteration of integrin β 4 expression.PloS one · 2014Article
- Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa.Genome medicine · 2014Article
- Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses.PloS one · 2013Article
- Profiling of differentially expressed genes using suppression subtractive hybridization in an equine model of chronic asthma.PloS one · 2012Article
- Transcriptional Changes of Blood Eosinophils After Methacholine Inhalation Challenge in Asthmatics.Genomics insights · 2012Article
- Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Host lung gene expression patterns predict infectious etiology in a mouse model of pneumonia.Respiratory research · 2010Article
- Integrating genomic and clinical medicine: searching for susceptibility genes in complex lung diseases.Translational research : the journal of laboratory and clinical medicine · 2008Review
- Mechanisms of occupational asthma: Not all allergens are equal.Environmental health and preventive medicine · 2007Article
- SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3).Atlas of genetics and cytogenetics in oncology and haematologyArticle
- Genetic Variants Associated with Bronchial Asthma Specific to the Population of the Russian Federation.Acta naturaeArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Asthma is a chronic inflammatory disease of the lungs, characterized by airway hyperreactivity, mucus hypersecretion, and airflow obstruction. Despite recent advances, the genetic regulation of asthma pathogenesis is still largely unknown. Gene expression profiling techniques are well suited to study complex diseases and hold substantial promise for identifying novel genes and pathways in asthma; however, relatively few studies have been completed in human asthma. The few studies that have been done have identified many novel candidate genes and pathways in asthma pathogenesis, including ALOX15 and serine proteinase inhibitors cathepsin C and G. The interpretation of results of these studies should be cautious, as limitations include small sample sizes and heterogeneity of study populations and tissues sampled. In the future, the promise of gene expression studies would be enhanced by the use of larger sample sizes and attempts to standardize phenotype, sample collection techniques, and analysis. As the field of expression profiling in asthma advances, we hope it will improve our understanding of critical questions about mechanisms involved in susceptibility to the disease, as well as help to personalize care by improving appropriate selection of patients for prevention and treatment strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.