ReviewProceedings of the American Thoracic Society2007
Gene-environment interactions in asthma: with apologies to William of Ockham.
Review in Proceedings of the American Thoracic Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 83 citations in OpenAlex.
- TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.The Journal of clinical investigation · 2015Trial
- Severe Asthma and Biological Therapies: Now and the Future.Journal of clinical medicine · 2023Review
- Is preterm birth associated with asthma among children from birth to 17 years old? -A study based on 2011-2012 US National Survey of Children's Health.Italian journal of pediatrics · 2018Article
- Immune monitoring for precision medicine in allergy and asthma.Current opinion in immunology · 2017Review
- Toward precision medicine and health: Opportunities and challenges in allergic diseases.The Journal of allergy and clinical immunology · 2016Review
- A toll-like receptor 4 (TLR4) variant is associated with asthma severity.International journal of clinical and experimental medicine · 2015Article
- Allergic diseases: the price of civilisational progress.Postepy dermatologii i alergologii · 2014Review
- Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.The Journal of allergy and clinical immunology · 2013Article
- Article
- Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice.American journal of respiratory cell and molecular biology · 2011Article
- Poor replication of candidate genes for major depressive disorder using genome-wide association data.Molecular psychiatry · 2011Article
- Immunological and genetic aspects of asthma and allergy.Journal of asthma and allergy · 2010Article
- Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits.The American journal of psychiatry · 2010Review
- Gene--environment-wide association studies: emerging approaches.Nature reviews. Genetics · 2010Review
- Assessment of DNA damage by RAPD in Paracentrotus lividus embryos exposed to amniotic fluid from residents living close to waste landfill sites.Journal of biomedicine & biotechnology · 2010Article
- Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma.Clinics in laboratory medicine · 2009Article
- Diet and asthma: looking back, moving forward.Respiratory research · 2009Article
- Analyses of associations with asthma in four asthma population samples from Canada and Australia.Human genetics · 2009Article
- Human rhinoviruses: the cold wars resume.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2008Review
- The nexus between atopic disease and autoimmunity: a review of the epidemiological and mechanistic literature.Clinical and experimental immunology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Many environmental factors and a large number of genetic polymorphisms have been reported to be associated with asthma risk in different locales and at different ages. It seems that what we call asthma is a heterogeneous set of conditions for which the only common feature is recurrent airway obstruction that is at least partially responsive to usual asthma therapy. Recent studies in which environmental factors and genetic variants were studied concomitantly have suggested a potential unifying concept for the disease. It seems that asthma is a genetically mediated development dysregulation of diverse immune and airway responses to a variety of specific and nonspecific exposures. It thus seems improbable that most genetic variants associated with asthma influence the disease regardless of which environmental factors trigger it and at which lifetime phase they are present. More likely, the most important gene variants for asthma are polymorphisms that exert their influence on the network system controlling biological responses to asthma-related exposures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.