ArticleJournal of clinical microbiology2007
Use of outer surface protein repeat regions for improved genotyping of Staphylococcus epidermidis.
Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Characterization of the Human Plasma Biofilm Model (hpBIOM) to Identify Potential Therapeutic Targets for Wound Management of Chronic Infections.Microorganisms · 2024Article
- Phenotypic and genotypic characterization of Staphylococci causing breast peri-implant infections in oncologic patients.BMC microbiology · 2015Article
- Accumulation-associated protein enhances Staphylococcus epidermidis biofilm formation under dynamic conditions and is required for infection in a rat catheter model.Infection and immunity · 2015Article
- Structural basis of Staphylococcus epidermidis biofilm formation: mechanisms and molecular interactions.Frontiers in cellular and infection microbiology · 2015Review
- Characterization of ocular methicillin-resistant Staphylococcus epidermidis isolates belonging predominantly to clonal complex 2 subcluster II.Journal of clinical microbiology · 2014Article
- A multidrug-resistant Staphylococcus epidermidis clone (ST2) is an ongoing cause of hospital-acquired infection in a Western Australian hospital.Journal of clinical microbiology · 2012Article
- Variation of serine-aspartate repeats in membrane proteins possibly contributes to staphylococcal microevolution.PloS one · 2012Article
- Coagulase-negative staphylococci: update on the molecular epidemiology and clinical presentation, with a focus on Staphylococcus epidermidis and Staphylococcus saprophyticus.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Review
- Molecular characterization of an early invasive Staphylococcus epidermidis prosthetic joint infection.Microbial drug resistance (Larchmont, N.Y.) · 2011Article
- Rapid typing of neonatal Staphylococcus epidermidis isolates using polymerase chain reaction for repeat regions in surface protein genes.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
- Polyphyletic emergence of linezolid-resistant staphylococci in the United States.Antimicrobial agents and chemotherapy · 2010Article
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Authors and funding
2 authors.
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Abstract
Staphylococcus epidermidis is an important nosocomial pathogen, but little is known of its epidemiology. Accurate, reproducible typing systems would greatly improve epidemiologic investigations of S. epidermidis. The sequence-based typing technique most recently evaluated, multilocus sequence typing (MLST), often lacks discrimination and can be expensive. PCR and sequence-based analyses of the serine-aspartate repeat region of sdrG (Fbe) and the repeat region of the accumulation-associated protein gene (aap) were evaluated for the ability to discriminate among previously well-characterized S. epidermidis clinical isolates. Forty-eight strains were investigated, with sdrG found in 100% and aap found in 79% of all strains tested. Both genes demonstrated PCR product size and nucleotide sequence variation. Each system by itself gave an index of discrimination similar in value to that of MLST (0.924 and 0.953 compared to 0.96), but discrimination was further improved when combinations of the three systems were used. We conclude that typing systems using amino acid and nucleotide repeat regions of the S. epidermidis surface proteins SdrG and Aap show promise as typing tools and should be investigated using a larger panel of clinically relevant isolates.
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