ArticleJournal of virology2007
Characterization of the nuclear export signal in the coronavirus infectious bronchitis virus nucleocapsid protein.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Characterization of nucleolar localization signals in the avian infectious bronchitis virus nucleocapsid protein and their critical role in viral replication.Journal of virology · 2026Article
- Attenuated Viral Replication of AvianMicrobiology spectrum · 2022Article
- Recent Progress in Torovirus Molecular Biology.Viruses · 2021Review
- Characterization of Localization and Export Signals of Bovine Torovirus Nucleocapsid Protein Responsible for Extensive Nuclear and Nucleolar Accumulation and Their Importance for Virus Growth.Journal of virology · 2021Article
- The nucleocapsid protein of human coronavirus NL63.PloS one · 2015Article
- Viruses and the nucleolus: the fatal attraction.Biochimica et biophysica acta · 2014Article
- The cellular interactome of the coronavirus infectious bronchitis virus nucleocapsid protein and functional implications for virus biology.Journal of virology · 2013Article
- Article
- Nucleolar proteomics and viral infection.Proteomics · 2010Review
- Article
- Quantitative proteomics using stable isotope labeling with amino acids in cell culture reveals changes in the cytoplasmic, nuclear, and nucleolar proteomes in Vero cells infected with the coronavirus infectious bronchitis virus.Molecular & cellular proteomics : MCP · 2010Article
- Involvement of the nucleolus in replication of human viruses.Reviews in medical virology · 2009Review
- Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus.Virology · 2008Article
- Article
- Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein.Virology · 2008Article
- Trafficking motifs in the SARS-coronavirus nucleocapsid protein.Biochemical and biophysical research communications · 2007Article
- Characterisation of cyclin D1 down-regulation in coronavirus infected cells.FEBS letters · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The nucleocapsid (N) protein of infectious bronchitis virus (IBV) localizes to the cytoplasm and nucleolus and contains an eight-amino-acid nucleolar retention motif. In this study, a leucine-rich nuclear export signal (NES) (291-LQLDGLHL-298) present in the C-terminal region of the IBV N protein was analyzed by using alanine substitution and deletion mutagenesis to investigate the relative contributions that leucine residues make to nuclear export and where these residues are located on the structure of the IBV N protein. The analysis indicated that Leu296 and Leu298 are required for efficient nuclear export of the protein. Structural information indicated that both of these amino acids are available for interaction with protein complexes involved in this process. However, export of N protein from the nucleus/nucleolus was not inhibited by leptomycin B treatment, indicating that N protein nuclear export is independent of the CRM1-mediated export pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.