ArticleJournal of virology2007
Understanding the failure of CD8+ T-cell vaccination against simian/human immunodeficiency virus.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- Increasing intrinsic protein disorder improves CD8+ immunogenicity for a SARS CoV2 vaccine candidate antigen.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Semi-infectious particles contribute substantially to influenza virus within-host dynamics when infection is dominated by spatial structure.Virus evolution · 2023Article
- Article
- Cancer-induced immunosuppression can enable effectiveness of immunotherapy through bistability generation: A mathematical and computational examination.Journal of theoretical biology · 2020Article
- Defining Kinetic Properties of HIV-Specific CD8⁺ T-Cell Responses in Acute Infection.Microorganisms · 2019Article
- Autologous Stem Cell Transplantation Disrupts Adaptive Immune Responses during Rebound Simian/Human Immunodeficiency Virus Viremia.Journal of virology · 2017Article
- Personalized life expectancy and treatment benefit index of antiretroviral therapy.Theoretical biology & medical modelling · 2017Article
- Notwithstanding Circumstantial Alibis, Cytotoxic T Cells Can Be Major Killers of HIV-1-Infected Cells.Journal of virology · 2016Article
- Timing of CD8 T cell effector responses in viral infections.Royal Society open science · 2016Article
- On the Role of CD8Frontiers in immunology · 2016Article
- Orally Administered Salacia reticulata Extract Reduces H1N1 Influenza Clinical Symptoms in Murine Lung Tissues Putatively Due to Enhanced Natural Killer Cell Activity.Frontiers in immunology · 2016Article
- Article
- The Effect of Interference on the CD8(+) T Cell Escape Rates in HIV.Frontiers in immunology · 2014Article
- Article
- Modeling antiretroviral drug responses for HIV-1 infected patients using differential equation models.Advanced drug delivery reviews · 2013Review
- Impaired immune evasion in HIV through intracellular delays and multiple infection of cells.Proceedings. Biological sciences · 2012Article
- Which of our modeling predictions are robust?PLoS computational biology · 2012Article
- A race between tumor immunoescape and genome maintenance selects for optimum levels of (epi)genetic instability.PLoS computational biology · 2012Article
- The role of recombination for the coevolutionary dynamics of HIV and the immune response.PloS one · 2011Article
- Implications of CTL-mediated killing of HIV-infected cells during the non-productive stage of infection.PloS one · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although CD8+ T cells play an important role in controlling viral infections, boosting specific CD8+ T cells by prophylactic vaccination with simian immunodeficiency virus (SIV) epitopes fails to provide sterilizing immunity. Viral replication rates and viral contraction rates after the peak viremia hardly depend on the presence of memory CD8+ T cells. To study these paradoxical findings, we parameterize novel mathematical models for acute SIV and human immunodeficiency virus infection. These models explain that failure of vaccination is due to the fact that effector/target ratios are too low during the viral expansion phase. Because CD8+ T cells require cell-to-cell contacts, immune protection requires high effector/target ratios at the primary site of infection. Effector/target ratios become favorable for immune control at the time of the peak in the viral load when the virus becomes limited by other factors, such as the availability of uninfected target cells. At the viral set point, effector/target ratios are much higher, and perturbations of the number of CD8+ effector cells have a large impact on the viral load. Such protective effector/target ratios are difficult to achieve with nucleic acid- or protein-based vaccines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.