ArticleNucleic acids research2007
DNA methylation immediately adjacent to active histone marking does not silence transcription.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- DNA methylation and lipid metabolism are involved in GA-induced maize aleurone layers PCD as revealed by transcriptome analysis.BMC plant biology · 2023Article
- Article
- Article
- Interplay between SIN3A and STAT3 mediates chromatin conformational changes and GFAP expression during cellular differentiation.PloS one · 2011Article
- Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease.PloS one · 2011Article
- A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth.EMBO reports · 2010Article
- DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker.Molecular biotechnology · 2010Review
- Epigenetics of human T cells during the G0-->G1 transition.Genome research · 2009Article
- Developmentally regulated extended domains of DNA hypomethylation encompass highly transcribed genes of the human beta-globin locus.Experimental hematology · 2009Article
- MBD4-mediated glycosylase activity on a chromatin template is enhanced by acetylation.Molecular and cellular biology · 2008Article
- An integrative genomic and epigenomic approach for the study of transcriptional regulation.PloS one · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Active promoters generally contain histone H3/H4 hyperacetylation and tri-methylation at H3 lysine 4, whereas repressed promoters are associated with DNA methylation. Here we show that the repressed erythroid-specific carbonic anhydrase II (CAII) promoter has active histone modifications localized around the transcription start, while high levels of CpG methylation are present directly upstream from these active marks. Despite the presence of active histone modifications, the repressed promoter requires hormone-induced activation for efficient preinitiation complex assembly. Transient and positional changes in histone H3/H4 acetylation and local changes in nucleosome density are evident during activation, but the bipartite epigenetic code is stably maintained. Our results suggest that active histone modifications may prevent spreading of CpG methylation towards the promoter and show that repressive DNA methylation immediately adjacent to a promoter does not necessarily repress transcription.
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Registered trials
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