ArticleThe Journal of cell biology1991
Vitronectin receptor has a role in bone resorption but does not mediate tight sealing zone attachment of osteoclasts to the bone surface.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 169 citations in OpenAlex.
- Vitronectin regulates osteoclastogenesis and bone remodeling in a mouse model of osteoporosis.Anatomy & cell biology · 2024Article
- Exosomal Osteoclast-Derived miRNA in Rheumatoid Arthritis: From Their Pathogenesis in Bone Erosion to New Therapeutic Approaches.International journal of molecular sciences · 2024Review
- Article
- Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease.Frontiers in pharmacology · 2020Article
- Non-Viral Delivery System and Targeted Bone Disease Therapy.International journal of molecular sciences · 2019Review
- Minor Review: An Overview of a Synthetic Nanophase Bone Substitute.Materials (Basel, Switzerland) · 2018Review
- Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss.Cell death and differentiation · 2015Article
- Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells.BioMed research international · 2015Review
- The α-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in β3 integrins.The Journal of biological chemistry · 2014Article
- Bone is not essential for osteoclast activation.PloS one · 2010Article
- CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts.Molecular biology of the cell · 2007Article
- Regulation of osteoclast polarization.Odontology · 2007Review
- Molecular regulation of osteoclast activity.Reviews in endocrine & metabolic disorders · 2006Review
- Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity.Molecular biology of the cell · 2005Article
- Apatite-mediated actin dynamics in resorbing osteoclasts.Molecular biology of the cell · 2004Article
- Roles of hyaluronan in bone resorption.BMC musculoskeletal disorders · 2004Review
- Impaired differentiation of osteoclasts in TREM-2-deficient individuals.The Journal of experimental medicine · 2003Article
- Elucidation of a common structure of selective fibrinogen receptor antagonists.Journal of computer-aided molecular design · 1998Article
- PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase.The Journal of clinical investigation · 1998Article
- Ultrastructural localization and biochemical characterization of vitronectin in developing rat bone.The Histochemical journal · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During bone resorption, osteoclasts form a tight attachment, the sealing zone, around resorption lacunae. Vitronectin receptor has previously been shown to be expressed in osteoclasts and it has been suggested that it mediates the tight attachment at the sealing zone. In this study we have shown that glycine-arginine-glycine-aspartic acid-serine pentapeptide inhibits bone resorption by isolated osteoclasts and drastically changes the morphology of the osteoclasts. When the vitronectin receptor was localized by immunofluorescence in rat and chicken osteoclasts cultured on bone slices, it was found to be distributed throughout the osteoclast cell membrane except in the sealing zone areas. Immunoperoxidase staining of rat bone sections at the light microscopical level also revealed intense staining of the cell membrane with occasional small unstained areas, probably corresponding to the sealing zones. Immunoelectron microscopy confirmed the results obtained by light microscopy showing specific labeling only at the ruffled borders and basolateral membranes (0.82 and 2.43 gold particles/microns of membrane, respectively), but not at the sealing zone areas (0.06 gold particles/microns of membrane). Both alpha v and beta 3 subunits of the vitronectin receptor were similarly localized. These results strongly suggest that, although the vitronectin receptor is important in the function of osteoclasts, it is not mediating the final sealing zone attachment of the osteoclasts to the mineralized bone surface.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.