Evidence map›Paper›PMID 17200946›Full record

ReviewThe Journal of pathology2007

Immunosenescence of ageing.

A L Gruver, L L Hudson, G D Sempowski

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 380 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
380citing papers in PubMed, 9 pooled it
17.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

380 citing papers in PubMed, 9 syntheses or guidelines pooled it, 832 citations in OpenAlex.

  1. Pooled it
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  5. Vaccines for preventing herpes zoster in older adults.The Cochrane database of systematic reviews · 2023
    Pooled it
  6. Vaccines for preventing herpes zoster in older adults.The Cochrane database of systematic reviews · 2019
    Pooled it
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320 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

A L GruverDuke University Human Vaccine Institute and Department of Pathology, Duke University Medical Center, Durham, NC, USA.
L L Hudson
G D Sempowski
Duke Medical Center · US

Funding

Regional Biocontainment Laboratory (RBL)UC6AI058607 · NIAID · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 2003 to 2005
$16.3M
Mechanisms of Age Induced Thymic AtrophyR01AG025150 · NIA · DUKE UNIVERSITY · PI SEMPOWSKI, GREGORY D · 2005 to 2009
$1.5M
NIAID NIH HHS UC6 AI058607NIA NIH HHS R01 AG025150
6 · The paper itself

Abstract

Ageing is a complex process that negatively impacts the development of the immune system and its ability to function. The mechanisms that underlie these age-related defects are broad and range from defects in the haematopoietic bone marrow to defects in peripheral lymphocyte migration, maturation and function. The thymus is a central lymphoid organ responsible for production of naïve T cells, which play a vital role in mediating both cellular and humoral immunity. Chronic involution of the thymus gland is thought to be one of the major contributing factors to loss of immune function with increasing age. It has recently been demonstrated that thymic atrophy is mediated by a shift from a stimulatory to a suppressive cytokine microenvironment. In this review we present an overview of the morphological, cellular and biochemical changes that have been implicated in the decline of thymic and peripheral immune function with ageing. We conclude with the clinical implications of age-associated immunosenescence to vaccine development for tumours and infectious disease. A fundamental understanding of the complex mechanisms by which ageing attenuates immune function will enable translational research teams to develop new therapies and vaccines specifically aimed at overcoming these defects in immunological function in the aged.

Indexed as

AgedAged, 80 and overAgingAtrophyB-LymphocytesBone Marrow CellsCommunicable DiseasesHematopoiesisHumansLymphoid TissueNeoplasmsStem CellsThymus GlandT-LymphocytesT-Lymphocytes, RegulatoryVaccinesVaccines

Identifiers

PMID17200946
PMCPMC1931833
OpenAlexW2080808232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.