ArticleEuropean journal of clinical pharmacology2007
Evaluation of the prescription and utilization patterns of statins in an Italian local health unit during the period 1994-2003.
Article in European journal of clinical pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of statin adherence on cardiovascular disease and mortality outcomes: a systematic review.British journal of clinical pharmacology · 2014Pooled it
- A systematic review of economic evaluations of interventions to tackle cardiovascular disease in low- and middle-income countries.BMC public health · 2012Pooled it
- Long-Lasting Control of LDL Cholesterol Induces a 40% Reduction in the Incidence of Cardiovascular Events: New Insights from a 7-Year Study.The Journal of pharmacology and experimental therapeutics · 2024Article
- Article
- Time trends in statin use and incidence of recurrent cardiovascular events in secondary prevention between 1999 and 2013: a registry-based study.BMC cardiovascular disorders · 2018Article
- Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes - The PROLONG-Steno study.Journal of clinical & translational endocrinology · 2017Article
- 10-year trends in statin utilization in Taiwan: a retrospective study using Taiwan's National Health Insurance Research Database.BMJ open · 2017Article
- Gender differences in statin prescription rates, adequacy of dosing, and association of statin therapy with outcome after heart failure hospitalization: a retrospective analysis in a community setting.European journal of clinical pharmacology · 2016Article
- Trends in statin therapy initiation during the period 2000-2010 in Israel.European journal of clinical pharmacology · 2014Article
- The impact of cost-sharing schemes on drug compliance in Italy: evidence based on quantile regression.International journal of public health · 2014Article
- Article
- Standardizing terminology and definitions of medication adherence and persistence in research employing electronic databases.Medical care · 2013Article
- Persistence with statin therapy in Hungary.Archives of medical science : AMS · 2013Article
- Adherence with statins in a real-life setting is better when associated cardiovascular risk factors increase: a cohort study.BMC cardiovascular disorders · 2011Article
- Medication adherence: WHO cares?Mayo Clinic proceedings · 2011Article
- Efficacy, effectiveness and real life goal attainment of statins in managing cardiovascular risk.Vascular health and risk management · 2009Review
- Shift of statin use towards the elderly in 1995-2005: a nation-wide register study in Finland.British journal of clinical pharmacology · 2008Article
- Lipid-lowering drug use in Italian primary care: effects of reimbursement criteria revision.European journal of clinical pharmacology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe prescription pattern of statins in the Local Health Unit (LHU) of Treviso (northern Italy) over a 10-year period was evaluated, with the aim of evaluating the persistence with and adherence to therapy.
methodsData on 21,393 subjects who received at least one prescription for statins during the period between January 1, 1994 and December 31, 2003 were retrieved from the LHU database in order to track the pharmacological history of individual patients. The data included age, sex, drug formulation, strength, number of drug packages prescribed, and prescription date. The adopted indicators for drug utilization included the Defined Daily Dose (DDD), the Received Daily Dose (RDD), and a surrogated Prescribed Daily Dose (sPDD), extrapolated from available prescription data. An Adherence to Therapy Index (ATI) was calculated from the ratio between the amount of drug actually prescribed and the amount of sPDD. Based on the ATI, patients were grouped into non-adherent, poor-adherent, and good-adherent groups. The distribution of adherence level among patient-age classes and statin-prescribed patients in primary or secondary prevention was evaluated.
resultsAll drug-utilization indicators showed an increase in statin use over the study period in terms of both the number of prescribed patients and the sPDD. Persistence with and adherence to therapy remained low, with a 50% discontinuation rate in the first year, and persistent patients did not follow the therapy regularly. Patients in secondary prevention were the most adherent to their drug regimen, although only 41% of these had a good compliance.
conclusionsOur findings suggest an increase in statin use which is, however, accompanied by poor patient persistence with and adherence to statin therapy.
Indexed as
Identifiers
17200832What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.