Evidence map›Paper›PMID 17200712›Full record

ArticleThe Journal of clinical investigation2007

Macrophage heterogeneity and tissue lipids.

Siamon Gordon

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed.

  1. Review
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  11. Aloperine suppresses LPS-induced macrophage activation through inhibiting the TLR4/NF-κB pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020
    Article
  12. World journal of gastroenterology · 2019
    Article
  13. Remote Postischemic Conditioning Promotes Stroke Recovery by Shifting Circulating Monocytes to CCR2The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  14. Review
  15. Article
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  20. Transcriptional Profiling of Immune-Related Genes inFrontiers in cellular and infection microbiology · 2018
    Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Siamon GordonSir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom. siamon.gordon@path.ox.ac.uk

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages are present as resident cells in adipose tissue, and blood monocytes are recruited in increased numbers to sites of lipid accumulation in atherosclerosis, a modified form of inflammation in the arterial wall. Recent findings reported by 3 separate groups in this issue of the JCI provide evidence for distinct monocyte subsets, differential chemokine receptor usage, and phenotypic modulation of macrophages in murine models of genetic and high-fat diet-induced disease (see the related articles beginning on pages 175, 185, and 195). These studies raise prospects for selective therapeutic targets to ameliorate macrophage hyperinflammatory responses, while sparing host defense and repair mechanisms.

Indexed as

Adipose TissueAnimalsDisease Models, AnimalFetal BloodHumansLipidsMacrophage ActivationMacrophagesMonocytesLipids

Identifiers

PMID17200712
PMCPMC1716225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.