Evidence map›Paper›PMID 17200702›Full record

ReviewThe Journal of clinical investigation2007

Gastrointestinal regulation of food intake.

David E Cummings, Joost Overduin

3 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of clinical investigation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 414 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
414citing papers in PubMed, 4 pooled it
31.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05578703 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Gastric Fundus Ablation Plus Endoscopic Sleeve Gastroplasty for Weight Loss

TypeinterventionalSponsorTrue You Weight LossRan2022 to 2026Enrolled10ConditionsObesityArmsFundic Ablation Sequentially in Combination with Endoscopic Sleeve Gastroplasty, Fundic Mucosal Ablation with ERBE HybridAPC, Apollo ESG
NCT05992103 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Single-Stage Gastric Fundus Ablation and Endoscopic Sleeve Gastroplasty for Weight Loss

TypeinterventionalSponsorTrue You Weight LossRan2023 to 2025Enrolled10ConditionsObesityArmsFundic Ablation in Combination with Endoscopic Sleeve Gastroplasty, Fundic Mucosal Ablation with ERBE HybridAPC, Apollo ESG
NCT06420700 recruitingnot on this mapstarted 2024, after this paper: background citation

A Multi-site, Prospective Registry of Patients Undergoing Combined Gastric Mucosal Ablation With Endoscopic Sleeve Gastroplasty at True You Weight Loss

Typeobservational_patient_registrySponsorTrue You Weight LossRan2024 to 2028Enrolled100ConditionsObesityArmsCombined gastric mucosal ablation with endoscopic sleeve gastroplasty
3 · Its place in the literature

Who cites it

414 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,185 citations in OpenAlex.

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354 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David E CummingsDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA. davidec@u.wasington.edu
Joost Overduin
University of Washington · US

Funding

Integration of Long- and Short-Term Control of FeedingP01DK068384 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2004 to 2010
$6.1M
Meal Initiation and Energy Homeostasis: Role of GhrelinR01DK061516 · NIDDK · UNIVERSITY OF WASHINGTON · PI CUMMINGS, DAVID EUSTACE · 2002 to 2009
$1.6M
NIDDK NIH HHS P01 DK068384NIDDK NIH HHS P01 DK68384NIDDK NIH HHS R01 DK061516NIDDK NIH HHS R01 DK61516
6 · The paper itself

Abstract

Despite substantial fluctuations in daily food intake, animals maintain a remarkably stable body weight, because overall caloric ingestion and expenditure are exquisitely matched over long periods of time, through the process of energy homeostasis. The brain receives hormonal, neural, and metabolic signals pertaining to body-energy status and, in response to these inputs, coordinates adaptive alterations of energy intake and expenditure. To regulate food consumption, the brain must modulate appetite, and the core of appetite regulation lies in the gut-brain axis. This Review summarizes current knowledge regarding the neuroendocrine regulation of food intake by the gastrointestinal system, focusing on gastric distention, intestinal and pancreatic satiation peptides, and the orexigenic gastric hormone ghrelin. We highlight mechanisms governing nutrient sensing and peptide secretion by enteroendocrine cells, including novel taste-like pathways. The increasingly nuanced understanding of the mechanisms mediating gut-peptide regulation and action provides promising targets for new strategies to combat obesity and diabetes.

Indexed as

Energy IntakeAdipose TissueGastrointestinal TractGhrelinHomeostasisHumansModels, BiologicalPeptide HormonesPeptide YYSatiety ResponseGhrelinPeptide HormonesPeptide YY

Identifiers

PMID17200702
PMCPMC1716217
OpenAlexW2082113374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.